A combined biochemical and cell biology approach to improve the pharmacological treatment of PH1: from pyridoxine derivatives to proteostasis regulators

Starting date
October 1, 2012
Duration (months)
30
Managers or local contacts
Cellini Barbara

Project participants

Elisa Oppici
Carla Voltattorni
Emeritus Professor
Publications
Title Authors Year
Allele-specific Characterization of Alanine: Glyoxylate Aminotransferase Variants Associated with Primary Hyperoxaluria Jose M. Sanchez-Ruiz;Melissa D. Lage;Adrianne M. C. Pittman;Alessandro Roncador;Barbara Cellini;Chandra L. Tucker 2014
PLP-Dependent Enzymes Alessandro Paiardini;Roberto Contestabile;Ashley M. Buckle;Barbara Cellini 2014
Gly161 mutations associated with Primary Hyperoxaluria Type I induce the cytosolic aggregation and the intracellular degradation of the apo-form of alanine:glyoxylate aminotransferase Elisa Oppici;Alessandro Roncador;Riccardo Montioli;Silvia Bianconi;Barbara Cellini 2013

Activities

Research facilities