Pubblicazioni

Autori:

Romanelli, Maria; Lorenzi, Pamela; Sangalli, Antonella; Diani, Erica; Mottes, Monica

Titolo:

Characterization and functional analysis of cis-acting elements of the human farnesyl diphosphate synthetase (FDPS) gene 5' flanking region.

Anno:

2009

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Genomics

ISSN Rivista:

0888-7543

N° Volume:

93

Numero o Fascicolo:

3

Intervallo pagine:

227-234

Parole chiave:

FPP; promoter analysis; farnesyl diphospate synthase; FDPS

Breve descrizione dei contenuti:

Farnesyl diphosphate synthetase (FDPS) is a key enzyme in the isoprenoid pathway responsible for cholesterol biosynthesis, post-translational protein modifications and synthesis of steroid hormones, whose expression is regulated by phorbol esters and polyunsaturated fatty acids. Genomic comparison of the 5' upstream sequence of the FDPS genes identifies conserved binding sites for NF-Y, SP1, SRE3, and YY1 regulatory elements in rat, mouse, dog and chimpanzee. Two additional specific consensus sequences, upstream of the core promoter that had not been analysed previously, are shared only by human and chimpanzee genomes. The work presented here aimed at characterizing these genomic sequence elements in the human FDPS promoter region and their contribution to gene expression. We have characterized functionally the minimal basal promoter of the human FDPS gene by means of deletion mutants and we have identified two cis-acting elements which modulate the FDPS gene expression and are recognized by Pax5 and OCT-1 transcription factors.

Pagina Web:

http://www.ncbi.nlm.nih.gov/pubmed/19056481

Id prodotto:

48760

Handle IRIS:

11562/324833

depositato il:

24 febbraio 2012

ultima modifica:

16 novembre 2022

Citazione bibliografica:

Romanelli, Maria; Lorenzi, Pamela; Sangalli, Antonella; Diani, Erica; Mottes, Monica, Characterization and functional analysis of cis-acting elements of the human farnesyl diphosphate synthetase (FDPS) gene 5' flanking region. «Genomics» , vol. 93 , n. 3 , 2009 , pp. 227-234

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