Publications

Authors:

Turci, Marco; Racchiolli, Pierpaolo; Ziglio, Serena; Astone, Dalila; Blanco, A.; Zipeto, Donato

Title:

HLA-C associates with Env and Increases HIV-1 infectivity

Year:

2011

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

No

Name of journal:

JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

ISSN of journal:

1525-4135

Number or Folder:

56

:

Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320

Page numbers:

65-65

Keyword:

HIV-1 AIDS HLA-C

Short description of contents:

Host cell proteins are specifically incorpo- rated into HIV-1 envelope during budding. Virionic HLA- C reduces HIV-1 susceptibility to neutralizing antibodies (Cosma 1999). A polymorphism in the 5’ region of the HLA- C gene has been associated to individual variations in set point viral loads (Fellay 2007), suggesting a role of HLA-C expression levels in modulating HIV-1 infectivity. We have reported (Matucci 2008; Baroni 2010) that HLA-C in the HIV-1 envelope associates to Env increasing viral infectivity of both R5 and X4 tropic viruses. The purpose of this study is to elucidate this interaction and exploit it for generating new immunogens capable of conferring protective immunity.

Web page:

http://journals.lww.com/jaids/Fulltext/2011/04002/157a_HLA_C_Associates_with_Env_and_Increases_HIV_1.54.aspx

Product ID:

61970

Handle IRIS:

11562/363237

Deposited On:

June 21, 2012

Last Modified:

November 1, 2022

Bibliographic citation:

Turci, Marco; Racchiolli, Pierpaolo; Ziglio, Serena; Astone, Dalila; Blanco, A.; Zipeto, Donato, HLA-C associates with Env and Increases HIV-1 infectivity «JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES» , n. 56 , 2011 , pp. 65-65

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