Publications

Authors:

Cisterna, Barbara; Malatesta, Manuela

Title:

Molecular and structural alterations of skeletal muscle tissue nuclei during aging

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ISSN of journal:

1422-0067

N° Volume:

25

Number or Folder:

3

Page numbers:

1-22

Keyword:

cell nucleus; chromatin; gene expression; ribonucleic acid (RNA) transcription; RNA processing; myofiber; satellite cell; skeletal muscle atrophy

Short description of contents:

Aging is accompanied by a progressive loss of skeletal muscle mass and strength. The mechanisms underlying this phenomenon are certainly multifactorial and still remain to be fully elucidated. Changes in the cell nucleus structure and function have been considered among the possible contributing causes. This review offers an overview of the current knowledge on skeletal muscle nuclei in aging, focusing on the impairment of nuclear pathways potentially involved in age-related muscle decline. In skeletal muscle two types of cells are present: fiber cells, constituting the contractile muscle mass and containing hundreds of myonuclei, and the satellite cells, i.e., the myogenic mononuclear stem cells occurring at the periphery of the fibers and responsible for muscle growth and repair. Research conducted on different experimental models and with different methodological approaches demonstrated that both the myonuclei and satellite cell nuclei of aged skeletal muscles undergo several structural and molecular alterations, affecting chromatin organization, gene expression, and transcriptional and post-transcriptional activities. These alterations play a key role in the impairment of muscle fiber homeostasis and regeneration, thus contributing to the age-related decrease in skeletal muscle mass and function.

Web page:

https://doi.org/10.3390/ijms25031833

Product ID:

137536

Handle IRIS:

11562/1118610

Last Modified:

June 12, 2024

Bibliographic citation:

Cisterna, Barbara; Malatesta, Manuela, Molecular and structural alterations of skeletal muscle tissue nuclei during aging «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES» , vol. 25 , n. 3 , 2024 , pp. 1-22

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo