Publications

Authors:

Marco Turci, Julie Lodewick, Paola Righi, Angela Polania, Maria Grazia Romanelli, Françoise Bex, Umberto Bertazzoni

Title:

HTLV-2B Tax oncoprotein is modified by ubiquitination and sumoylation and displays intracellular localization similar to its homologue HTLV-1 Tax.

Year:

2009

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Nations of authors:

BELGIO; ITALIA

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Virology

ISSN of journal:

0042-6822

N° Volume:

386

Series:

0042-6822

Number or Folder:

1

Page numbers:

6-11

Code PMID:

19195675

Keyword:

HTLV Tax CREB NF-κB Ubiquitination Sumoylation Nuclear bodies

Note:

HTLV-1 is more pathogenic than HTLV-2B. The difference is generally attributed to the properties of their individual transactivating Tax proteins. By using internal Flag-6His tagged Tax-1 and Tax-2B, which display transcriptional activities comparable to the untagged proteins and can be recognized by a single anti-Flag antibody, we demonstrate that Tax-2B is modified by ubiquitination and sumoylation. In addition, Tax2B is distributed in punctuate nuclear structures that include the RelA subunit of NF-kappaB, as has been previously demonstrated for Tax-1.

Product ID:

48907

Handle IRIS:

11562/-327503

Deposited On:

March 1, 2009

Last Modified:

March 1, 2009

Bibliographic citation:

Marco Turci, Julie Lodewick, Paola Righi, Angela Polania, Maria Grazia Romanelli, Françoise Bex, Umberto Bertazzoni, HTLV-2B Tax oncoprotein is modified by ubiquitination and sumoylation and displays intracellular localization similar to its homologue HTLV-1 Tax. «Virology» , vol. 386 , n. 1 ,  0042-6822 , 2009 , pp. 6-11

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