Publications

Authors:

Avesani, F.; Romanelli, Maria; Turci, M.; DI GENNARO, Gianfranco; Sampaio, C.; Bidoia, C.; Bertazzoni, U.; Bex, F.

Title:

Association of HTLV Tax proteins with TAK1-binding protein 2 and RelA in calreticulin-containing cytoplasmic structures partecipates in Tax-mediated NF-KB activation.

Year:

2010

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Virology

ISSN of journal:

0042-6822

N° Volume:

408

Number or Folder:

1

Page numbers:

39-48

Keyword:

Calreticulin; HTLV; NF-κB; RelA; Signalling; TAB2; Tax; Transactivation;

Short description of contents:

HTLV-1 is more pathogenic than HTLV-2 despite having a similar genome and closely related transactivating oncoproteins. Both Tax-1 protein from HTLV-1 and Tax-2 from HTLV-2 activate the NF-κB pathway. The mechanisms involved in Tax-1 deregulation of this signalling pathway have been thoroughly investigated, but little is known about regulation by Tax-2. We have compared the interaction of Tax-1 and Tax-2 with two key NF-κB signalling factors: TAK1-binding protein 2 (TAB2), an adaptor involved in the activation of TAK1 kinase, and RelA, the active subunit of the canonical RelA/p50 NF-κB transcription factor. Tax-2 formed stable complexes with both RelA and TAB2. These two NF-κB factors colocalized with Tax proteins in dotted cytoplasmic structures targeted by calreticulin, a multi-process calcium-buffering chaperone. Co-expression of RelA and/or TAB2 markedly increased Tax-mediated NF-κB activation. These findings provide new insights into the role of RelA, TAB2 and Tax in the deregulation of the NF-κB pathway.

Web page:

http://www.ncbi.nlm.nih.gov/pubmed/20875659

Product ID:

60582

Handle IRIS:

11562/352798

Deposited On:

February 21, 2012

Last Modified:

November 15, 2022

Bibliographic citation:

Avesani, F.; Romanelli, Maria; Turci, M.; DI GENNARO, Gianfranco; Sampaio, C.; Bidoia, C.; Bertazzoni, U.; Bex, F., Association of HTLV Tax proteins with TAK1-binding protein 2 and RelA in calreticulin-containing cytoplasmic structures partecipates in Tax-mediated NF-KB activation. «Virology» , vol. 408 , n. 1 , 2010 , pp. 39-48

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