Olfactory mucosa brushing coupled with RT-QuIC: a potential and innovative test for intravital definite diagnosis of Creutzfeldt Jakob disease

Starting date
January 1, 2014
Duration (months)
Neurosciences, Biomedicine and Movement Sciences
Managers or local contacts
Zanusso Gianluigi

Aim of the present project is to provide a standard procedure for OM sampling and to analyse the sensitivity and the specificity of OM brushing/RT-QuIC test in a large cohort of patients with sporadic CJD and genetic CJD.
Its purpose is to foster and validate a diagnostic test for the definite intravital diagnosis of Creutzfeldt – Jakob disease (CJD) based on the identification of the pathological prion protein (PrPCJD) in the olfactory mucosa (OM) collected by nasal brushing.


The Foundation pour la Recherche Medicale (FRM)
Funds: assigned and managed by the department

Project participants

Matilde Bongianni
Temporary Assistant Professor
Michele Fiorini
Scholarship holder
Gianluigi Zanusso
Associate Professor


  • pdf   Progetto   (pdf, it, 59 KB, 26/03/14)


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