Publications

Authors:

Cavallieri, Francesco; Gessani, Annalisa; Merlo, Andrea; Campanini, Isabella; Budriesi, Carla; Fioravanti, Valentina; Di Rauso, Giulia; Feletti, Alberto; Damiano, Benedetta; Scaltriti, Sara; Guagnano, Noemi; Bardi, Elisa; Corni, Maria Giulia; Antonelli, Francesca; Cavalleri, Francesca; Molinari, Maria Angela; Contardi, Sara; Menozzi, Elisa; Puzzolante, Annette; Vannozzi, Giuseppe; Bergamini, Elena; Pavesi, Giacomo; Fraix, Valérie; Meoni, Sara; Fraternali, Alessandro; Versari, Annibale; Lusuardi, Mirco; Biagini, Giuseppe; Pinto, Serge; Moro, Elena; Valzania, Franco

Title:

Interplay between speech and gait variables in PD patients treated with STN-DBS: a long-term instrumental assessment

Year:

2023

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

European Journal Of Neurology

ISSN of journal:

1351-5101

N° Volume:

30

Number or Folder:

7

Page numbers:

1963-1972

Keyword:

Parkinson's Disease; STN-DBS; deep brain stimulation; gait; levodopa; speech

Short description of contents:

Objective: To evaluate correlations between speech and gait parameters in the long-term and under different medication and subthalamic nucleus deep brain stimulation (STN-DBS) conditions in a cohort of advanced Parkinson's Disease (PD) patients. Methods: This observational study included consecutive PD patients treated with bilateral STN-DBS. Axial symptoms were evaluated using a standardized clinical-instrumental approach. Speech and gait were assessed by perceptual and acoustic analyses and by the instrumented timed up and go test (iTUG) respectively. Disease motor severity was evaluated with the total score and subscores of the UPDRS part III. Different stimulation and drug treatment conditions were assessed: on-stimulation/off-medication, off-stimulation/off-medication, and on-stimulation/on-medication. Results: Twenty-five PD patients with a five-year median follow-up after surgery (range 3-7) were included (18 M; disease duration at surgery:10.44 [sd:4.62] years; age at surgery:58.40 [sd:5.73] years). In the off-stimulation/off-medication and on-stimulation/on-medication conditions, patients who spoke louder had also the greater acceleration of the trunk during gait whereas, in the on-stimulation/on-medication condition only, patients with the poorer voice quality were also the worse to perform sit to stand and gait phases of the iTUG. On the contrary, patients with the higher speech rate performed well the turning and walking phases of the iTUG. Conclusions: This study underlines the presence of different correlations between treatment effects of speech and gait parameters in PD patients treated with bilateral STN-DBS. This may allow us to better understand the common pathophysiological basis of these alterations and to develop a more specific and tailored rehabilitation approach for axial signs after surgery.

Web page:

https://doi.org/10.1111/ene.15803

Product ID:

133067

Handle IRIS:

11562/1089728

Last Modified:

June 8, 2023

Bibliographic citation:

Cavallieri, Francesco; Gessani, Annalisa; Merlo, Andrea; Campanini, Isabella; Budriesi, Carla; Fioravanti, Valentina; Di Rauso, Giulia; Feletti, Alberto; Damiano, Benedetta; Scaltriti, Sara; Guagnano, Noemi; Bardi, Elisa; Corni, Maria Giulia; Antonelli, Francesca; Cavalleri, Francesca; Molinari, Maria Angela; Contardi, Sara; Menozzi, Elisa; Puzzolante, Annette; Vannozzi, Giuseppe; Bergamini, Elena; Pavesi, Giacomo; Fraix, Valérie; Meoni, Sara; Fraternali, Alessandro; Versari, Annibale; Lusuardi, Mirco; Biagini, Giuseppe; Pinto, Serge; Moro, Elena; Valzania, Franco, Interplay between speech and gait variables in PD patients treated with STN-DBS: a long-term instrumental assessment «European Journal Of Neurology» , vol. 30 , n. 7 , 2023 , pp. 1963-1972

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