A combined biochemical and cell biology approach to improve the pharmacological treatment of PH1: from pyridoxine derivatives to proteostasis regulators

Starting date: October 1, 2012
Duration (months): 30
Managers or local contacts: Cellini Barbara

Project participants

Barbara Cellini
Mirco Dindo
Riccardo Montioli: Associate Professor

Elisa Oppici
Carla Voltattorni: Emeritus Professor

Research areas involved in the project
Proteomica strutturale, funzionale e di espressione Biochemistry & Molecular Biology (DBT)
Biochimica e Biologia Molecolare Biochemistry & Molecular Biology (DBT) (DBT)
Proteomica strutturale, funzionale e di espressione Biochemistry & Molecular Biology (DM) (DM)
Biochimica e Biologia Molecolare Biochemistry & Molecular Biology (DM) (DM)
Proteomica strutturale, funzionale e di espressione Biochemistry & Molecular Biology (DNBM) (DNBM)
Biochimica e Biologia Molecolare Biochemistry & Molecular Biology (DNBM) (DNBM)
Proteomica strutturale, funzionale e di espressione Biochemistry & Molecular Biology (DSVR) (DSVR)
Biochimica e Biologia Molecolare Biochemistry & Molecular Biology (DSVR)

Sections
Biological Chemistry Section

Publications
Title	Authors	Year
Allele-specific Characterization of Alanine: Glyoxylate Aminotransferase Variants Associated with Primary Hyperoxaluria	Jose M., Sanchez Ruiz; Melissa D., Lage; Adrianne M. C., Pittman; Roncador, Alessandro; Cellini, Barbara; Chandra L., Tucker	2014
PLP-Dependent Enzymes	Alessandro, Paiardini; Roberto, Contestabile; Ashley M., Buckle; Cellini, Barbara	2014
Gly161 mutations associated with Primary Hyperoxaluria Type I induce the cytosolic aggregation and the intracellular degradation of the apo-form of alanine:glyoxylate aminotransferase	Oppici, Elisa; Roncador, Alessandro; Montioli, Riccardo; Bianconi, Silvia; Cellini, Barbara	2013