Characterization in purified recombinant form of human ornithine aminotransferase (OAT), an enzyme associated with gyrate atrophy of the choroid and retina, a rare genetic disorder with autosomal recessive transmission. At molecular level, the project involves the characterization of both the native form and the pathogenic variants using spectroscopic, kinetic, chromatographic and computational techniques, and at the cellular level the use of appropriate cellular models
Aree di ricerca coinvolte dal progetto | |
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Proteomica strutturale, funzionale e di espressione
Biochemistry & Molecular Biology (DBT) |
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Proteomica strutturale, funzionale e di espressione
Biochemistry & Molecular Biology (DM) (DM) |
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Proteomica strutturale, funzionale e di espressione
Biochemistry & Molecular Biology (DNBM) (DNBM) |
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Proteomica strutturale, funzionale e di espressione
Biochemistry & Molecular Biology (DSVR) |
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Biomedicina |
Sezioni | |
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Chimica Biologica |
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