Biochemistry & Molecular Biology

People with expertise in this area
Research interests

Mariarita Bertoldi: Associate Professor
Elena Butturini: Associate Professor
Ilaria Dando: Associate Professor
Daniele Dell'Orco: Associate Professor
Massimo Donadelli: Full Professor

Giovanni Gotte: Associate Professor
Sofia Giovanna Mariotto: Associate Professor
Marta Vittoria Menegazzi: Associate Professor
Marta Palmieri: Research Assistants
Donato Zipeto: Full Professor

Research interests
Topic	People	Description
Biochimica delle patologie neoplastiche e andrologiche	Ilaria Dando	Studio delle alterazioni biochimiche alla base dell'insorgenza, dello sviluppo e della progressione di patologie neoplastiche e andrologiche, soprattutto dell'età pediatrica.
Biophysical Chemistry	Daniele Dell'Orco	Physical and Systems Biochemistry, nanobiophysics, molecular basis of retinal diseases, protein-nanodevice interactions, structure-function properties in protein complexes, neuronal calcium sensors, bioinformatics and systems biology
Enzymology and Protein chemistry	Mariarita Bertoldi	studio della chimica delle proteine e dei meccanismi di funzionamento degli enzimi
EVs technology for anti-inflammatory natural compound delivery	Elena Butturini	My research activity focuses on the development and engineering of extracellular vesicles (EVs) as innovative delivery systems for natural compounds with anti-inflammatory and antioxidant properties. EVs derived from different biological matrices are investigated and optimized for the targeted transport of bioactive molecules and recombinant proteins, with particular attention to the modulation of inflammatory pathways and oxidative stress. The overall goal is to develop translational strategies with potential applications in the biomedical, nutraceutical, and cosmetic fields, integrating advanced biotechnologies with natural bioactive compounds.
Genome editing	Donato Zipeto	Development of genome editing protocols using CRISPR / Cas9 and knock-out cell lines; analysis of the role of β2-microglobulin in the etiology of neurodegenerative diseases.
Molecular mechanisms of the antitumoral activity of various compounds	Marta Palmieri	Innovative strategies to inhibit prolifaration of pancreatic adenocarcinoma in in vitro and in vivo models
Meccanismi molecolari di chemioresistenza in cellule di cancro del pancreas	Massimo Donadelli	Strategie innovative per inibire la proliferazione cellulare dell'adenocarcinoma pancreatico in modelli cellulari e animali. Meccanismi molecolari oncogenici indotti da p53 mutata. Regolazione trascrizionale mediante modificazioni epigenetiche; regolazione dello stress ossidativo e dei meccanismi molecolari dell'autofagia nel cancro.
Meccanismi protettivi di fitocomposti in sistemi cellulari modello di patologie	Marta Vittoria Menegazzi	Analisi biochimiche dei meccanismi protettivi di fitocomposti in sistemi cellulari modello di patologie
Oxidative stress and inflammation	Sofia Giovanna Mariotto	- Functional cross-talk between constitutive and nitric oxide synthase. Modulation of NO production in in vitro inflammatory models. - Molecular mechanism of apoptotic activity of natural compounds towards tumoral cells. - Oxidative stress and post-translational modifications of the transcription factor STATs.
Struttura e funzione di aggregati proteici	Giovanni Gotte	Studi strutturali e funzionali di multimeri e oligomeri proteici, in paricolare di varie ribonucleasi di tipo pancreatico, ottenibili tramite modifiche chimiche e/o cross linking, o attraverso aggregazione proteica tramite scambio tridimensionale di domini.