Molecular and Cellular Biology of Bone (2020/2021)

Course code
cod wi: DT000126
Name of lecturer
Monica Mottes
Coordinator
Monica Mottes
Number of ECTS credits allocated
2
Academic sector
BIO/13 - EXPERIMENTAL BIOLOGY
Language of instruction
Italian
Location
VERONA
Period
A.A. 20/21 dottorato dal Oct 1, 2020 al Sep 30, 2021.

Lesson timetable

Go to lesson schedule

Learning outcomes

To deepen PhD students' knowledge about bone/cartilage cellular and molecular biology.
The course aim is to update current knowledge with discussion/illustration of reviews and research papers published recently

Syllabus

Osteogenesis
Bone homeostasis
Bone composition
Bone extracellular matrix
Cells types in bone
The mineralization process
Molecular pathways controlling osteogenic differentiation of progenitor cells
Cells-ECM interactions in bone
The role of autophagy in bone biology
Bone mineral density; alterations; Osteoporosis
Genetic diseases which exemplify opposite defects in osteogenesis:
OSTEOGENESIS IMPERFECTA- clinical description, classification, genetic heterogeneity, molecular genetics
OSTEOPETROSIS- clinical description, classification, genetic heterogeneity, molecular genetics
Cartilage: cells and ECM composition. Molecular and cellulare bases of cartilage degeneration and dysfunctions

Reference books
Author Title Publisher Year ISBN Note
Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff Molecular Biology of the Cell (Edizione 7) Garland Science 2017 0815344643 English edition

Assessment methods and criteria

PhD students who choose this topic are supposed to participate to the 8 hrs course.
No final examination is foreseen