Combining vitamin E-functionalized CHOcolate with physical exercise to reduce the risK Of protein energy malnutrition in pre-dementia AGEd people. CHOKO-AGE

Starting date
June 10, 2021
Duration (months)
36
Departments
Neurosciences, Biomedicine and Movement Sciences
Managers or local contacts
Venturelli Massimo
URL
www.chokoage.eu

The Choko-agE  granted project consists in the development of a vitamin E-functionalized chocolate rich in polyphenols to be studied during a randomized clinical trial in combination with physical exercise to prevent protein-energy malnutrition in a defined population of elderly patients affected by cognitive decline. More in detail, in our project we hypothesize that the antioxidant and cytoprotective functions of vitamin E, may combine with the cortisol lowering effect of chocolate polyphenols and physical exercise, to help preventing muscle loss (primary end-point in the study) in these elderly patients. Besides to muscle mass, a multiomics approach will be implemented to explore underlying biological and molecular pathways beyond clinical manifestations of protein-energy malnutrition and the response to the proposed intervention, including skeletal muscle mitochondrial function and nutrient metabolism, insulin and cortisol signaling, and enzymatic and free radical-derived metabolites of vitamin E that will be explored for the first time in the human muscle.

Sponsors:

JPI
Funds: assigned and managed by the department

Project participants

Chiara Milanese
Associate Professor
Anna Pedrinolla
Professor from another university
Federico Schena
Full Professor
Massimo Venturelli
Associate Professor

Collaboratori esterni

Federico Galli
Università di Perugia
Mario Rende
Università di Perugia
Vincenzo Nicola Talesa
Università di Perugia
Cinzia Antonielli
Università di Perugia
Anna Maria Stabile
Università di Perugia
Desiree Bartolini
Università di Perugia
Rita Marinelli
Università di Perugia
Eivind Wang
University of Molde (NW)
Ole Kristian Brones Berg
University of Molde (NW)
Mathias Forsberg Brobakken
University of Molde (NW)
Tiril Tøien
University of Molde (NW)
Roberto Modena
University of Molde (NW)
Malcom Jackson
University of Liverpool (GB)
Anne McArdle
University of Liverpool (GB)
Masoud Isanejad
University of Liverpool (GB)
Kay Hemmings
University of Liverpool (GB)
Konstantinos Prokopidis
University of Liverpool (GB)
Jose Viña
Inclivia VLC (SP)
Consuelo Borrás
Inclivia VLC (SP)
Aurora Román
Inclivia VLC (SP)
Cristina Mas
Inclivia VLC (SP)

Activities

Research facilities