Meningeal lymphoid-like structures as secret EBV hideout in multiple sclerosis

Starting date
October 1, 2023
Duration (months)
12
Departments
Neurosciences, Biomedicine and Movement Sciences
Managers or local contacts
Magliozzi Roberta

In order to test the hypothesis that Epstein-Barr virus (EBV) plays a fundamental role in multiple sclerosis (MS), by hiding in intracerebral niches, such as meningeal tertiary lymphoid-like structures (TLS) and driving intrathecal chronic inflammation, we propose to verify the presence and frequency/level of EBV-infected B cells within MS meningeal TLS in post-mortem MS cases, by using new integrative neuropathological and in situ sequencing techniques. This project will help to identify the specific cell and molecular profile of meningeal EBV-infected B cells and interacting cells in MS meningeal TLS by using spatial-omics.

Sponsors:

National Multiple Sclerosis Society (NMSS)
Funds: assigned and managed by the department

Project participants

Roberta Magliozzi
Associate Professor
Research areas involved in the project
Neurosciences

Activities

Research facilities

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