- Authors:
-
Marco Turci, Julie Lodewick, Paola Righi, Angela Polania, Maria Grazia Romanelli, Françoise Bex, Umberto Bertazzoni
- Title:
-
HTLV-2B Tax oncoprotein is modified by ubiquitination and sumoylation and displays intracellular localization similar to its homologue HTLV-1 Tax.
- Year:
-
2009
- Type of item:
-
Articolo in Rivista
- Tipologia ANVUR:
- Articolo su rivista
- Nations of authors:
-
BELGIO;
ITALIA
- Language:
-
Inglese
- Format:
-
A Stampa
- Referee:
-
Sì
- Name of journal:
- Virology
- ISSN of journal:
- 0042-6822
- N° Volume:
-
386
- Series:
-
0042-6822
- Number or Folder:
-
1
- Page numbers:
-
6-11
- Code PMID:
-
19195675
- Keyword:
-
HTLV Tax CREB NF-κB Ubiquitination Sumoylation Nuclear bodies
- Note:
- HTLV-1 is more pathogenic than HTLV-2B. The difference is generally attributed to the properties of their individual transactivating Tax proteins. By using internal Flag-6His tagged Tax-1 and Tax-2B, which display transcriptional activities comparable to the untagged proteins and can be recognized by a single anti-Flag antibody, we demonstrate that Tax-2B is modified by ubiquitination and sumoylation. In addition, Tax2B is distributed in punctuate nuclear structures that include the RelA subunit of NF-kappaB, as has been previously demonstrated for Tax-1.
- Product ID:
-
48907
- Handle IRIS:
-
11562/-327503
- Deposited On:
-
March 1, 2009
- Last Modified:
-
March 1, 2009
- Bibliographic citation:
-
Marco Turci, Julie Lodewick, Paola Righi, Angela Polania, Maria Grazia Romanelli, Françoise Bex, Umberto Bertazzoni,
HTLV-2B Tax oncoprotein is modified by ubiquitination and sumoylation and displays intracellular localization similar to its homologue HTLV-1 Tax.
«Virology»
, vol.
386
, n.
1
,
0042-6822
,
2009
,
pp. 6-11
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