- Autori:
-
Marco Turci, Julie Lodewick, Paola Righi, Angela Polania, Maria Grazia Romanelli, Françoise Bex, Umberto Bertazzoni
- Titolo:
-
HTLV-2B Tax oncoprotein is modified by ubiquitination and sumoylation and displays intracellular localization similar to its homologue HTLV-1 Tax.
- Anno:
-
2009
- Tipologia prodotto:
-
Articolo in Rivista
- Tipologia ANVUR:
- Articolo su rivista
- Nazioni degli autori:
-
BELGIO;
ITALIA
- Lingua:
-
Inglese
- Formato:
-
A Stampa
- Referee:
-
Sì
- Nome rivista:
- Virology
- ISSN Rivista:
- 0042-6822
- N° Volume:
-
386
- Serie:
-
0042-6822
- Numero o Fascicolo:
-
1
- Intervallo pagine:
-
6-11
- Codice PMID:
-
19195675
- Parole chiave:
-
HTLV Tax CREB NF-κB Ubiquitination Sumoylation Nuclear bodies
- Note:
- HTLV-1 is more pathogenic than HTLV-2B. The difference is generally attributed to the properties of their individual transactivating Tax proteins. By using internal Flag-6His tagged Tax-1 and Tax-2B, which display transcriptional activities comparable to the untagged proteins and can be recognized by a single anti-Flag antibody, we demonstrate that Tax-2B is modified by ubiquitination and sumoylation. In addition, Tax2B is distributed in punctuate nuclear structures that include the RelA subunit of NF-kappaB, as has been previously demonstrated for Tax-1.
- Id prodotto:
-
48907
- Handle IRIS:
-
11562/-327503
- depositato il:
-
1 marzo 2009
- ultima modifica:
-
1 marzo 2009
- Citazione bibliografica:
-
Marco Turci, Julie Lodewick, Paola Righi, Angela Polania, Maria Grazia Romanelli, Françoise Bex, Umberto Bertazzoni,
HTLV-2B Tax oncoprotein is modified by ubiquitination and sumoylation and displays intracellular localization similar to its homologue HTLV-1 Tax.
«Virology»
, vol.
386
, n.
1
,
0042-6822
,
2009
,
pp. 6-11
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