Publications

Authors:

Arru, Giannina; Sechi, Elia; Mariotto, Sara; Zarbo, Ignazio R.; Ferrari, Sergio; Gajofatto, Alberto; Monaco, Salvatore; Deiana, Giovanni A.; Bo, Marco; Sechi, Leonardo A.; Sechi, Gian Pietro

Title:

Antibody response against HERV-W in patients with MOG-IgG associated disorders, multiple sclerosis and NMOSD

Year:

2020

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Journal of Neuroimmunology

ISSN of journal:

0165-5728

N° Volume:

338

Number or Folder:

577110

Page numbers:

1-5

Keyword:

autoimmunity; human endogenous retroviruses; MS; myelin oligodendrocyte glycoprotein; neuromyelitis optica spectrum disorder

Short description of contents:

Increased expression of the retroviruses of HERV-W family has been linked to multiple sclerosis (MS) pathophysiology; nothing is known at the moment about MOG-IgG associated disorders. We compared antibody response against HERV-W peptides among patients with MOG-IgG associated disorders, multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG positive neuromyelitis optica spectrum disorder (NMOSD). A total of 102 serum samples were retrospectively analyzed. Antibody reactivity against HERV-W env peptides was similar in MOG-IgG associated disorders and MS, but different from AQP4-IgG positive NMOSD. Our findings expand the diagnostic role of HERV-W antibodies to the spectrum of demyelinating disorders associated with MOG-IgG.

Web page:

https://doi.org/10.1016/j.jneuroim.2019.577110

Product ID:

111048

Handle IRIS:

11562/1003377

Last Modified:

November 17, 2022

Bibliographic citation:

Arru, Giannina; Sechi, Elia; Mariotto, Sara; Zarbo, Ignazio R.; Ferrari, Sergio; Gajofatto, Alberto; Monaco, Salvatore; Deiana, Giovanni A.; Bo, Marco; Sechi, Leonardo A.; Sechi, Gian Pietro, Antibody response against HERV-W in patients with MOG-IgG associated disorders, multiple sclerosis and NMOSD «Journal of Neuroimmunology» , vol. 338 , n. 577110 , 2020 , pp. 1-5

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