Publications

Authors:

Chinello, Matteo; Balter, Rita; De Bortoli, Massimiliano; Vitale, Virginia; Zaccaron, Ada; Bonetti, Elisa; Tonin, Paola; Vattemi, Gaetano; Guglielmi, Valeria; Cesaro, Simone

Title:

Chronic graft-versus-host-disease-related polymyositis: a 17-months-old child with a rare and late complication of haematopoietic stem cell transplantation

Year:

2020

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES

ISSN of journal:

2035-3006

N° Volume:

12

Number or Folder:

e2020002

Page numbers:

1-5

Keyword:

chronic graft-versus-host-disease; emapalumab; hemophagocytic lymphohistiocytosis; methylprednisolone; polymyositis; rituximab; sirolimus

Short description of contents:

Background: Chronic graft versus host disease (cGVHD) occurs in 20-30% of paediatric patients receiving haemopoietic stem cell transplantation (HSCT). Neuromuscular disorders such as polymyositis are considered a rare and distinctive but non-diagnostic manifestation of cGVHD and, in the absence of other characteristic signs and symptoms, biopsy is highly recommended to exclude other causes. Case report: We report a case of a 17-months-old child affected by hemophagocytic lymphohistiocytosis who underwent a matched unrelated donor haematopoietic stem cell transplantation (HSCT). She developed severe cGVHD-related polymyositis that was successfully treated with high-dose steroid therapy, rituximab and sirolimus. Conclusions: This is the first case of cGVHD-related-polymyositis described in a pediatric patient which was successfully treated with rituximab.

Web page:

https://doi.org/10.4084/mjhid.2020.002

Product ID:

111790

Handle IRIS:

11562/1009455

Last Modified:

November 28, 2022

Bibliographic citation:

Chinello, Matteo; Balter, Rita; De Bortoli, Massimiliano; Vitale, Virginia; Zaccaron, Ada; Bonetti, Elisa; Tonin, Paola; Vattemi, Gaetano; Guglielmi, Valeria; Cesaro, Simone, Chronic graft-versus-host-disease-related polymyositis: a 17-months-old child with a rare and late complication of haematopoietic stem cell transplantation «MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES» , vol. 12 , n. e2020002 , 2020 , pp. 1-5

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo