Pubblicazioni

Autori:

Fioravanzo, Adele; Caffo, Maria; Di Bonaventura, Rina; Gardiman, Marina Paola; Ghimenton, Claudio; Ius, Tamara; Maffeis, Valeria; Martini, Maurizio; Nicolato, Antonio; Pallini, Roberto; Pegolo, Enrico; Pinna, Giampietro; Sala, Francesco; Skrap, Miran; Volpin, Valerio; Barresi, Valeria

Titolo:

A risk score based on 5 clinico-pathological variables predicts recurrence of atypical meningiomas

Anno:

2020

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Journal of Neuropathology and Experimental Neurology

ISSN Rivista:

0022-3069

N° Volume:

79

Numero o Fascicolo:

5

Intervallo pagine:

500-507

Parole chiave:

Atypical meningioma; Mitosis; Recurrence; Sheeting; Simpson

Breve descrizione dei contenuti:

The use of adjuvant radiotherapy is controversial in patients with atypical meningiomas treated with gross total resection (GTR). This study aimed to determine whether clinico-pathological features could be helpful to predict the recurrence risk in this group of patients and to identify high-risk ones who could benefit from adjuvant treatment. We collected 200 patients with primary atypical meningiomas treated with GTR but with no adjuvant radiotherapy from 5 different centers. A risk score, formulated by assigning 1 point for the presence and 0 points for the absence of 5 high-risk parameters (male sex, parasagittal site, Simpson grade 3, mitotic index ≥ 6/10 HPF, and sheeting), was the most significant predictor of recurrence. A score ≥2 was associated with 4.7 risk of shorter disease-free survival (p < 0.0001). Our findings indicate that the presence of at least 2 clinico-pathological high-risk factors predicts recurrence of totally resected primary atypical meningiomas and could be helpful for identifying patients who could benefit from adjuvant radiotherapy.

Pagina Web:

https://doi.org/10.1093/jnen/nlaa018

Id prodotto:

113789

Handle IRIS:

11562/1014921

ultima modifica:

14 novembre 2022

Citazione bibliografica:

Fioravanzo, Adele; Caffo, Maria; Di Bonaventura, Rina; Gardiman, Marina Paola; Ghimenton, Claudio; Ius, Tamara; Maffeis, Valeria; Martini, Maurizio; Nicolato, Antonio; Pallini, Roberto; Pegolo, Enrico; Pinna, Giampietro; Sala, Francesco; Skrap, Miran; Volpin, Valerio; Barresi, Valeria, A risk score based on 5 clinico-pathological variables predicts recurrence of atypical meningiomas «Journal of Neuropathology and Experimental Neurology» , vol. 79 , n. 5 , 2020 , pp. 500-507

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