Publications

Authors:

Mattioli, Flavia; Bellomi, F; Stampatori, C; Mariotto, S; Ferrari, S; Monaco, S; Mancinelli, C; Capra, R

Title:

Longitudinal serum neurofilament light chain (sNfL) concentration relates to cognitive function in multiple sclerosis patients

Year:

2020

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Journal of Neurology

ISSN of journal:

0340-5354

N° Volume:

267

Number or Folder:

8

Page numbers:

2245-2251

Keyword:

Cognitive impairment; Longitudinal; Multiple sclerosis; Neurofilaments

Short description of contents:

BACKGROUND: Serum neurofilament light chain (sNfL) may be used as a biological marker of disease progression in multiple sclerosis (MS), although longitudinal studies correlating cognitive deficits to sNfL are limited. OBJECTIVE: To longitudinally investigate the relation between cognitive dysfunction, sNfL and MRI brain volume in a relapsing remitting MS patients. METHODS: 18 MS patients (9 males and 9 females, mean age 45 years, mean education 12.6 years) all prescribed with interferon beta 1a (44 mcg 3 times per week), are longitudinally evaluated by means of annual clinical exam with EDSS, neuropsychological evaluation with Brief repeatable battery (BRB) and Delis Kaplan Executive function test (DKEFS), dosage of sNfL (SIMOA) and MRI. RESULTS: Here are reported the results of 1 year follow-up. A significantly higher sNfL in MS compared to healthy controls and higher sNfL in patients with greater cognitive impairment were found. Cognitive Impairment Index, memory, executive function tests correlated with sNfL. Gray matter volume resulted unchanged at 1-year follow-up; a weak correlation between some tests' score and selective cortical brain areas was found. CONCLUSION: Our longitudinal pilot study confirms that sNfL are related to cognitive abilities, confirming data of other authors from retrospective studies

Web page:

https://doi.org/10.1007/s00415-020-09832-1

Product ID:

114031

Handle IRIS:

11562/1016125

Last Modified:

November 15, 2022

Bibliographic citation:

Mattioli, Flavia; Bellomi, F; Stampatori, C; Mariotto, S; Ferrari, S; Monaco, S; Mancinelli, C; Capra, R, Longitudinal serum neurofilament light chain (sNfL) concentration relates to cognitive function in multiple sclerosis patients «Journal of Neurology» , vol. 267 , n. 8 , 2020 , pp. 2245-2251

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo