Pubblicazioni

Autori:

Magliozzi, Roberta; Scalfari, Antonio; Pisani, Anna Isabella; Ziccardi, Stefano; Marastoni, Damiano; Pizzini, Francesca Benedetta; Bajrami, Albulena; Tamanti, Agnese; Guandalini, Maddalena; Bonomi, Samuele; Rossi, Stefania; Mazziotti, Valentina; Castellaro, Marco; Montemezzi, Stefania; Rasia, Sarah; Capra, Ruggero; Pitteri, Marco; Romualdi, Chiara; Reynolds, Richard; Calabrese, Massimiliano

Titolo:

The CSF profile linked to cortical damage predicts Multiple Sclerosis activity

Anno:

2020

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Annals of Neurology

ISSN Rivista:

0364-5134

N° Volume:

88

Numero o Fascicolo:

3

Intervallo pagine:

562-573

Parole chiave:

multiple sclerosis; cerebrospinal fluid; cortical damage; MRI; intrathecal inflammation; disease activity risk

Breve descrizione dei contenuti:

OBJECTIVE: Intrathecal inflammation correlates with the grey matter damage since the early stages of Multiple Sclerosis (MS), but whether the cerebrospinal fluid (CSF) profile can help to identify patients at risk of disease activity is still unclear. METHODS: We evaluated the association between CSF levels of 18 cytokines, previously found to be associated to grey matter damage, and the disease activity, among 99 relapsing-remitting MS patients, who underwent blinded clinical and 3T-MRI evaluations for 4 years. Groups with (EDA) or without (NEDA) evidence of disease activity (occurrence of relapses, new white matter lesions, EDSS change) were identified. Cortical lesions and the annualized cortical thinning were also evaluated. RESULTS: Fortyone patients experienced EDA and, compared to the NEDA group, had at diagnosis higher CSF levels of CXCL13, CXCL12, IFNγ, TNF, sCD163, LIGHT and APRIL (p<0.001). In the multivariate analysis, CXCL13 (HR=1.35, p=0.0002), LIGHT (HR=1.22, p=0.005) and APRIL (HR=1.78, p=0.0001) were the CSF molecules more strongly associated with the risk of EDA. The model including CSF variables predicted more accurately the occurrence of disease activity than the model with only clinical/MRI parameters (C-index at 4 years= 71% vs 44%). Finally, higher CSF levels of CXCL13 (β=4.7*10-4 ,p<0.001), TNF (β=3.1*10-3 ,p=0.004), LIGHT (β=2.6*10-4 ,p=0.003), sCD163 (β=4.3*10-3 ,p=0.009) and TWEAK (β=3.4*10-3 ,p=0.024) were associated with more severe cortical thinning. INTERPRETATION: A specific CSF profile, mainly characterized by elevated levels of B-cell related cytokines, distinguishes patients at high risk of disease activity and severe cortical damage. The CSF analysis may allow stratifications of patients at diagnosis for optimizing therapeutic approaches. This article is protected by copyright. All rights reserved.

Pagina Web:

https://doi.org/10.1002/ana.25786

Id prodotto:

114507

Handle IRIS:

11562/1018303

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Magliozzi, Roberta; Scalfari, Antonio; Pisani, Anna Isabella; Ziccardi, Stefano; Marastoni, Damiano; Pizzini, Francesca Benedetta; Bajrami, Albulena; Tamanti, Agnese; Guandalini, Maddalena; Bonomi, Samuele; Rossi, Stefania; Mazziotti, Valentina; Castellaro, Marco; Montemezzi, Stefania; Rasia, Sarah; Capra, Ruggero; Pitteri, Marco; Romualdi, Chiara; Reynolds, Richard; Calabrese, Massimiliano, The CSF profile linked to cortical damage predicts Multiple Sclerosis activity «Annals of Neurology» , vol. 88 , n. 3 , 2020 , pp. 562-573

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo