Publications

Up-regulated serum miR-128-3p in progressive and relapse-free multiple sclerosis patients  (2020)

Authors:
Zanoni, Mattia; Orlandi, Elisa; Rossetti, Giulia; Turatti, Marco; Calabrese, Massimiliano; Gomez Lira, Macarena; Gajofatto, Alberto
Title:
Up-regulated serum miR-128-3p in progressive and relapse-free multiple sclerosis patients
Year:
2020
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
A Stampa
Referee:
Name of journal:
ACTA NEUROLOGICA SCANDINAVICA
ISSN of journal:
1600-0404
N° Volume:
142
Number or Folder:
5
Page numbers:
511-516
Keyword:
mir-128-3p; multiple sclerosis; biomarkers; serum; disease activity; disease progression
Short description of contents:
Background: Circulating microRNAs have emerged as novel multiple sclerosis (MS) biomarkers. Aims: To assess the association between candidate miRs expression in serum samples of patients with MS and the disease course. Methods: Serum levels of ten microRNAs (i.e. miR-199, miR-128-3p, miR-20a-5p, miR-27a-3p, miR-15b-5p, miR-325, miR-92a1-5p, miR-223-5p, miR-22-5p, and miR-23a-5p) were measured in 74 MS cases and 17 non-MS controls consecutively enrolled at Verona University Hospital. The association of microRNAs expression with patients' clinical and MRI features was analyzed. Candidate microRNAs were detected by Real-Time PCR and expressed as ratio of each microRNA level to a normalizer. Results: Serum miR-128-3p levels were higher in progressive than relapsing MS (median ratio 2.86 vs 0.73, p=0.036). In addition, miR-128-3p was up-regulated in patients without relapses after sample collection compared to cases who relapsed (1.64 vs 0.82; p=0.014). miR-128-3p levels and relapse rate were inversely correlated (r= -0.44, p=0.008). Conclusions: Serum levels of mir-128-3p could be related to biological mechanisms underlying MS activity and progression.
Web page:
https://doi.org/10.1111/ane.13288
Product ID:
114680
Handle IRIS:
11562/1018643
Last Modified:
November 15, 2022
Bibliographic citation:
Zanoni, Mattia; Orlandi, Elisa; Rossetti, Giulia; Turatti, Marco; Calabrese, Massimiliano; Gomez Lira, Macarena; Gajofatto, Alberto, Up-regulated serum miR-128-3p in progressive and relapse-free multiple sclerosis patients «ACTA NEUROLOGICA SCANDINAVICA» , vol. 142 , n. 52020pp. 511-516

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