Publications

Authors:

Orlandi, Riccardo; Mariotto, Sara; Ferrari, Sergio; Gobbin, Francesca; Sechi, Elia; Capra, Ruggero; Mancinelli, Chiara Rosa; Bombardi, Roberto; Zuliani, Luigi; Zoccarato, Marco; Rossi, Francesca; Camera, Valentina; Ferraro, Diana; Benedetti, Maria Donata; Reindl, Markus; Gajofatto, Alberto

Title:

Diagnostic features of initial demyelinating events associated with serum MOG-IgG

Year:

2020

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Journal of Neuroimmunology

ISSN of journal:

0165-5728

N° Volume:

344

Number or Folder:

577260

Page numbers:

1-6

Keyword:

Autoimmune diseases of the nervous system; Epidemiology; Immunology; MOG; Multiple sclerosis; Neuromyelitis optica

Short description of contents:

Background: Myelin oligodendrocyte glycoprotein (MOG)-IgG associated disorders are increasingly recognized as a distinct disease entity. However, diagnostic sensitivity and specificity of serum MOG-IgG as well as recommendations for testing are still debated. Materials and methods: Between October 2015 and July 2017 we tested serum MOG-IgG in 91 adult patients (49 females) with a demyelinating event (DE) not fulfilling 2010 McDonald criteria for MS at sampling, negative for neuromyelitis optica (NMO)-IgG and followed-up for at least 12 months. We assessed the sensitivity and specificity of a live-cell MOG-IgG assay for each final diagnosis at last follow-up, for the 2018 international recommendations for MOG-IgG testing, and for other combinations of clinical and laboratory characteristics. Results: Clinical presentations included acute myelitis (n = 48), optic neuritis (n = 36), multifocal encephalomyelitis (n = 4), and brainstem syndrome (n = 3). Twenty-four patients were MOG-IgG positive. Sensitivity and specificity of MOG-IgG test applied to the 2018 international recommendations were 28.4% and 86.7%, while they were 42.1% and 88.6% when applied to DE of unclear aetiology as defined above with two or more among: 1_no periventricular and juxtacortical MS-like lesions on brain MRI; 2_longitudinally extensive MRI optic nerve lesion; 3_no CSF-restricted oligoclonal bands; 4_CSF protein > 50 mg/dl. Conclusions: Simplified requirements compared to those currently proposed for MOG-IgG testing could facilitate the applicability of the assay in the diagnosis of adults with DEs of unclear aetiology.

Web page:

https://doi.org/10.1016/j.jneuroim.2020.577260

Product ID:

114675

Handle IRIS:

11562/1018644

Last Modified:

November 17, 2022

Bibliographic citation:

Orlandi, Riccardo; Mariotto, Sara; Ferrari, Sergio; Gobbin, Francesca; Sechi, Elia; Capra, Ruggero; Mancinelli, Chiara Rosa; Bombardi, Roberto; Zuliani, Luigi; Zoccarato, Marco; Rossi, Francesca; Camera, Valentina; Ferraro, Diana; Benedetti, Maria Donata; Reindl, Markus; Gajofatto, Alberto, Diagnostic features of initial demyelinating events associated with serum MOG-IgG «Journal of Neuroimmunology» , vol. 344 , n. 577260 , 2020 , pp. 1-6

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