Reduced minimum rim width of optic nerve head: a potential early marker of retinal neurodegeneration in children and adolescents with type 1 diabetes
(2020)
Reduced minimum rim width of optic nerve head: a potential early marker of retinal neurodegeneration in children and adolescents with type 1 diabetes
Year:
2020
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
Elettronico
Referee:
Sì
Name of journal:
Diabetes Research and Clinical Practice
ISSN of journal:
0168-8227
N° Volume:
169
Number or Folder:
108420
Page numbers:
1-9
Keyword:
Diabetic retinopathy; Minimal neuroretinal rim width; Retinal neurodegeneration; Spectral domain optical coherence tomography; Type 1 Diabetes
Short description of contents:
Aims: To determine whether early retinal neurodegenerative changes in pediatric patients with type 1 diabetes (T1D) can be detected by spectral domain-optical coherence tomography (SD-OCT) and whether such changes are associated with risk factors for T1D complications. Methods: A total of 147 T1D children/adolescents and 51 healthy controls underwent SD-OCT. Spherical refractive error (SRE), macular total retinal thickness (TRT), ganglion cell layer (GCL), retinal nerve fiber layer (RNFL), minimum rim width (MRW), and Bruch's membrane opening area (BMOA) were measured. Clinical and biochemical parameters were recorded at the time of SD-OCT and starting at T1D onset. Multiple regression models were calculated using SD-OCT parameters as dependent and risk factors as independent variables. Results: MRW was significantly thinner in the T1D patients (global MRW:361.58vs386.33µm;p=0.009), while RNFL and macular parameters were similar for both groups. MRW was inversely correlated with mean HbA1c (r≥-0.180,p<0.05). Multiple regression showed that part of the variability in MRW was explained by HbA1c and BMOA (R2 =0.21;p< 0.001), independent of other cardiometabolic risk factors. Conclusions: MRW reduction could be a potential early marker of retinal neurodegeneration detectable in pediatric patients with T1D. The association between MRW and mean HbA1c suggests that glucometabolic control may affect early retinal neurodegeneration starting in childhood.
Note:
Claudia Piona and Tiziano Cozzini contributed equally to this work.
Emilio Pedrotti and Claudio Maffeis contributed equally to this work.
Piona, Claudia; Cozzini, Tiziano; Marchini, Giorgio; Merz, Tommaso; Brighenti, Tommaso; Mazzo, Umberto; Marigliano, Marco; Olivieri, Francesca; Pedrotti, Emilio; Maffeis, Claudio,
Reduced minimum rim width of optic nerve head: a potential early marker of retinal neurodegeneration in children and adolescents with type 1 diabetes«Diabetes Research and Clinical Practice»
, vol. 169
, n. 108420
, 2020
, pp. 1-9