Pubblicazioni

Reduced minimum rim width of optic nerve head: a potential early marker of retinal neurodegeneration in children and adolescents with type 1 diabetes  (2020)

Autori:
Piona, Claudia; Cozzini, Tiziano; Marchini, Giorgio; Merz, Tommaso; Brighenti, Tommaso; Mazzo, Umberto; Marigliano, Marco; Olivieri, Francesca; Pedrotti, Emilio; Maffeis, Claudio
Titolo:
Reduced minimum rim width of optic nerve head: a potential early marker of retinal neurodegeneration in children and adolescents with type 1 diabetes
Anno:
2020
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Formato:
Elettronico
Referee:
Nome rivista:
Diabetes Research and Clinical Practice
ISSN Rivista:
0168-8227
N° Volume:
169
Numero o Fascicolo:
108420
Intervallo pagine:
1-9
Parole chiave:
Diabetic retinopathy; Minimal neuroretinal rim width; Retinal neurodegeneration; Spectral domain optical coherence tomography; Type 1 Diabetes
Breve descrizione dei contenuti:
Aims: To determine whether early retinal neurodegenerative changes in pediatric patients with type 1 diabetes (T1D) can be detected by spectral domain-optical coherence tomography (SD-OCT) and whether such changes are associated with risk factors for T1D complications. Methods: A total of 147 T1D children/adolescents and 51 healthy controls underwent SD-OCT. Spherical refractive error (SRE), macular total retinal thickness (TRT), ganglion cell layer (GCL), retinal nerve fiber layer (RNFL), minimum rim width (MRW), and Bruch's membrane opening area (BMOA) were measured. Clinical and biochemical parameters were recorded at the time of SD-OCT and starting at T1D onset. Multiple regression models were calculated using SD-OCT parameters as dependent and risk factors as independent variables. Results: MRW was significantly thinner in the T1D patients (global MRW:361.58vs386.33µm;p=0.009), while RNFL and macular parameters were similar for both groups. MRW was inversely correlated with mean HbA1c (r≥-0.180,p<0.05). Multiple regression showed that part of the variability in MRW was explained by HbA1c and BMOA (R2 =0.21;p< 0.001), independent of other cardiometabolic risk factors. Conclusions: MRW reduction could be a potential early marker of retinal neurodegeneration detectable in pediatric patients with T1D. The association between MRW and mean HbA1c suggests that glucometabolic control may affect early retinal neurodegeneration starting in childhood.
Note:
Claudia Piona and Tiziano Cozzini contributed equally to this work. Emilio Pedrotti and Claudio Maffeis contributed equally to this work.
Pagina Web:
https://doi.org/10.1016/j.diabres.2020.108420
Id prodotto:
115991
Handle IRIS:
11562/1024361
ultima modifica:
15 novembre 2022
Citazione bibliografica:
Piona, Claudia; Cozzini, Tiziano; Marchini, Giorgio; Merz, Tommaso; Brighenti, Tommaso; Mazzo, Umberto; Marigliano, Marco; Olivieri, Francesca; Pedrotti, Emilio; Maffeis, Claudio, Reduced minimum rim width of optic nerve head: a potential early marker of retinal neurodegeneration in children and adolescents with type 1 diabetes «Diabetes Research and Clinical Practice» , vol. 169 , n. 1084202020pp. 1-9

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo IRIS

<<indietro

Attività

Strutture

Condividi