Publications

Authors:

Kiani, Aysha Karim; Falsini, Benedetto; Ziccardi, Lucia; Gusson, Elena; Mangialavori, Domenica; Allegrini, Francesca; Colao, Emma; Bertelli, Matteo

Title:

Flavonoid supplements increase neurotrophin activity to modulate inflammation in retinal genetic diseases

Year:

2020

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

ACTA BIOMEDICA

ISSN of journal:

2531-6745

N° Volume:

91

Number or Folder:

13-S

Page numbers:

1-5

Keyword:

retinal degenerative disorders; neurotrophin synthesis; flavonoids supplementation; anti-inflammation; anti-oxidant

Short description of contents:

Retinal degenerative disorders induce loss of photoreceptors associated with inflammation, and negative remodeling and plasticity of neural retina. Retinal degenerative diseases may have genetic and/or environmental causes. Degeneration of retinal pigment epithelium cells initiates a vicious circle increasing the ongoing inflammation in both retina and choroid. Flavonoids are polyphenolic molecules with antioxidant activity and dietary intake, specifically of anthocyanins and flavanols, improves oxidative stress and neuro-inflammation. In vitro and ex vivo studies have also revealed biological effects of flavonoids on retinal protection against oxidative stress and inflammation. In this brief review, the protective role of flavonoids against retinal degeneration and inflammation will be discussed along with their therapeutic potential for the treatment of retinal degenerative diseases.

Web page:

https://doi.org/10.23750/abm.v91i13-S.10683

Product ID:

117492

Handle IRIS:

11562/1029615

Last Modified:

November 15, 2022

Bibliographic citation:

Kiani, Aysha Karim; Falsini, Benedetto; Ziccardi, Lucia; Gusson, Elena; Mangialavori, Domenica; Allegrini, Francesca; Colao, Emma; Bertelli, Matteo, Flavonoid supplements increase neurotrophin activity to modulate inflammation in retinal genetic diseases «ACTA BIOMEDICA» , vol. 91 , n. 13-S , 2020 , pp. 1-5

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