Publications

Authors:

Monaco, Salvatore; Mariotto, Sara; Ferrari, Sergio

Title:

Peripheral neuropathy and central nervous system involvement in cryoglobulinemia

Year:

2012

Type of item:

Contributo in volume (Capitolo o Saggio)

Tipologia ANVUR:

Contributo in volume (Capitolo o Saggio)

Language:

Inglese

Format:

A Stampa

Book Title:

HCV Infection and Cryoglobulinemia

Publisher:

Springer-Verlag Italia

ISBN:

978-88-470-1704-7

Page numbers:

209-217

Keyword:

peripheral neuropathy; sustained virological response; mixed cryoglobulinemia; axonal polyneuropathy; cold agglutinin disease

Short description of contents:

Cryoglobulins (CG) are immunoglobulins that persist in the serum and have the physical property of precipitating on exposure to cold and resolubilizing when returned to body temperature. Three categories of cryoglobulins are recognized, either essential or secondary to chronic hepatitis C virus (HCV) infection, autoimmune diseases, and lymphoproliferative disorders. Peripheral neuropathy (PN) can occur with all types of CG, although it is usually found in patients with HCV-associated type II CG. PN has different clinical manifestations, ranging from subclinical involvement to symmetrical or asymmetrical sensory, sensorimotor, or motor forms. The mechanisms of nerve involvement are related to small vessel vasculitis, complement-mediated microangiopathy, and HCV-triggered dysimmune responses. The central nervous system (CNS) can be also involved in CG and clinical manifestations are highly variegated. In recent years, the study of HCV-infected individuals has revealed an increased prevalence of cognitive changes and behavioral/neuropsychological symptoms, suggesting a major pathogenic role of HCV, following neuroinvasion and replication. Here, we review the range of neurological complications associated with essential and secondary CG and discuss the available therapeutic options.

Web page:

https://doi.org/10.1007/978-88-470-1705-4_26

Product ID:

118017

Handle IRIS:

11562/1031104

Last Modified:

November 8, 2022

Bibliographic citation:

Monaco, Salvatore; Mariotto, Sara; Ferrari, Sergio, Peripheral neuropathy and central nervous system involvement in cryoglobulinemia HCV Infection and Cryoglobulinemia , Springer-Verlag Italia , 2012 , pp. 209-217

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo