Pubblicazioni

Autori:

Tamburin, Stefano; Mantovani, Elisa; Bertoldi, Anna; Federico, Angela; Casari, Rebecca; Lugoboni, Fabio

Titolo:

High-dose dependence and cognitive side effects to medical prescription of etizolam

Anno:

2020

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

FRONTIERS IN PSYCHIATRY

ISSN Rivista:

1664-0640

N° Volume:

11

Numero o Fascicolo:

601827

Intervallo pagine:

1-5

Parole chiave:

BZD; benzodiazepine; cognition; dependence; etizolam; neuropsychology; substance use disorder (SUD)

Breve descrizione dei contenuti:

Introduction: The use of novel designer drugs has increased worldwide over the years. Etizolam is a designer benzodiazepine (BZD) that has raised concern because of its growing non-medical use, liability to tolerance and dependence, and related harms. Studies exploring the abuse liability and cognitive effects of etizolam outside the therapeutic doses are lacking.Aims: To explore the abuse liability of etizolam and the characteristics of patients affected by etizolam high-dose dependence in a nationwide tertiary referral addiction unit. To document the cognitive changes to etizolam high-dose use.Design and Methods: Sociodemographic and clinical data on subjects with etizolam high-dose use were retrospectively collected from a database of 1,293 patients consecutively admitted to the Addiction Medicine Unit, Verona University Hospital, Italy for detoxification from high-dose BZDs or Z-drugs dependence. Thorough neuropsychological testing explored the cognitive side effects of high-dose etizolam use.Results: We found eleven etizolam high-dose users, of which eight used etizolam only, and three used etizolam with other BZDs/zolpidem. All the patients were prescribed etizolam for medical reasons, i.e., anxiety and/or insomnia. Neuropsychological evaluation showed deficits of working memory, visuospatial memory and executive function in a 27-year-old woman who used etizolam 15 mg daily.Discussion: Our findings suggest that abuse and dependence liability of etizolam should be considered a public health and social problem. They offer preliminary evidence on the cognitive side effects of etizolam high-dose use.Conclusions: This report offers new information on the potential harms of etizolam in patients who are prescribed this drug for medical reasons.

Pagina Web:

https://doi.org/10.3389/fpsyt.2020.601827

Id prodotto:

118579

Handle IRIS:

11562/1032867

ultima modifica:

11 novembre 2022

Citazione bibliografica:

Tamburin, Stefano; Mantovani, Elisa; Bertoldi, Anna; Federico, Angela; Casari, Rebecca; Lugoboni, Fabio, High-dose dependence and cognitive side effects to medical prescription of etizolam «FRONTIERS IN PSYCHIATRY» , vol. 11 , n. 601827 , 2020 , pp. 1-5

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