Publications

Authors:

Martignon, Camilla; Ruzzante, Federico; Giuriato, Gaia; Laginestra, Fabio Giuseppe; Pedrinolla, Anna; Di Vico, Ilaria Antonella; Saggin, Paolo; Stefanelli, Donato; Tinazzi, Michele; Schena, Federico; Venturelli, Massimo

Title:

The key role of physical activity against the neuromuscular deterioration in patients with Parkinson's disease

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

ACTA PHYSIOLOGICA (PRINT)

ISSN of journal:

1748-1708

N° Volume:

231

Number or Folder:

e13630

:

Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: journals.cs@blacksci.co.uk, INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205

Page numbers:

1-14

Keyword:

Parkinson’s disease; muscle adaptations; muscle force

Short description of contents:

Aim: Decreased muscle strength has been frequently observed in individuals with Parkinson's disease (PD). However, this condition is still poorly examined in physically active patients. This study compared quadriceps (Q) maximal force, and the contribution of central and peripheral components of force production during a maximal isometric task between physically active PD and healthy individuals. In addition, the correlation between force determinants and energy expenditure indices were investigated. Methods: Maximal voluntary contraction (MVC), resting twitch force (RT), pennation angle (Θp), physiological cross-sectional area (PCSA), and Q volume were assessed in 10 physically-active PD and 10 healthy control (CTRL) individuals matched for age, sex, and daily energy expenditure (DEE) profile. Results: No significant differences were observed between PD and CTRL in MVC (142±85; 142±47 N m), Q volume (1469±379; 1466±522 cm3 ), PCSA (206±54; 205±71 cm2 ), Θp (14±7; 13±3 rad) and voluntary muscle specific torque [MVC/PCSA (67±35; 66±19 N m cm-2 )]. Daily calories and MVC correlated (r=0.56, p=0.0099). However, PD displayed lower maximal voluntary activation (MVA) (85±7; 95±5 %), rate of torque development (RTD) in the 0-0.05 s (110±70; 447±461 N m s-1 ) and the 0.05-0.1 s (156±135; 437±371 N m s-1 ) epochs of MVCs, whereas RT normalised for PCSA was higher (35±14; 20±6 N m cm-2 ). Conclusion: Physically active PDs show a preserved strength of the lower limb. This resulted by increasing skeletal muscle contractility, which counterbalances neuromuscular deterioration, likely due to their moderate level of physical activity.

Web page:

https://doi.org/10.1111/apha.13630

Product ID:

119499

Handle IRIS:

11562/1036939

Last Modified:

November 25, 2022

Bibliographic citation:

Martignon, Camilla; Ruzzante, Federico; Giuriato, Gaia; Laginestra, Fabio Giuseppe; Pedrinolla, Anna; Di Vico, Ilaria Antonella; Saggin, Paolo; Stefanelli, Donato; Tinazzi, Michele; Schena, Federico; Venturelli, Massimo, The key role of physical activity against the neuromuscular deterioration in patients with Parkinson's disease «ACTA PHYSIOLOGICA (PRINT)» , vol. 231 , n. e13630 , 2021 , pp. 1-14

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