Publications

Authors:

Mariotto, Sara; Gastaldi, Matteo; Grazian, Luisa; Mancinelli, Chiara; Capra, Ruggero; Marignier, Romaine; Alberti, Daniela; Zanzoni, Serena; Schanda, Kathrin; Franciotta, Diego; Calabria, Francesca; Monaco, Salvatore; Reindl, Markus; Ferrari, Sergio; Gajofatto, Alberto

Title:

NfL levels predominantly increase at disease onset in MOG-Abs-associated disorders

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

MULTIPLE SCLEROSIS AND RELATED DISORDERS

ISSN of journal:

2211-0348

N° Volume:

50

Number or Folder:

102833

Page numbers:

1-4

Keyword:

MOG; MOGAD; Myelitis; Neurofilament light chain levels; NfL; Optic neuritis

Short description of contents:

The unpredictable course and uncertain impact of relapses make treatment strategies of anti-myelin oligodendrocyte glycoprotein antibodies associated disorders (MOGAD) challenging. We analysed neurofilament light chain levels (NfL) in onset and follow-up sera of 18 patients with MOGAD to clarify the timing of axonal damage. In comparison with disease onset values (median 8.9 pg/mL, range 1.8-97), NfL levels remained stable or decreased in most follow-up measurements (n=52, median 6.7 pg/mL, range 0.2-207), including those measured on relapses. The predominant axonal damage occurs during onset, which could be the main driving factor of final disability, with subsequent relevant clinical and therapeutic implications.

Web page:

https://doi.org/10.1016/j.msard.2021.102833

Product ID:

119504

Handle IRIS:

11562/1037061

Last Modified:

November 9, 2022

Bibliographic citation:

Mariotto, Sara; Gastaldi, Matteo; Grazian, Luisa; Mancinelli, Chiara; Capra, Ruggero; Marignier, Romaine; Alberti, Daniela; Zanzoni, Serena; Schanda, Kathrin; Franciotta, Diego; Calabria, Francesca; Monaco, Salvatore; Reindl, Markus; Ferrari, Sergio; Gajofatto, Alberto, NfL levels predominantly increase at disease onset in MOG-Abs-associated disorders «MULTIPLE SCLEROSIS AND RELATED DISORDERS» , vol. 50 , n. 102833 , 2021 , pp. 1-4

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