Pubblicazioni

Autori:

Mariotto, Sara; Gastaldi, Matteo; Grazian, Luisa; Mancinelli, Chiara; Capra, Ruggero; Marignier, Romaine; Alberti, Daniela; Zanzoni, Serena; Schanda, Kathrin; Franciotta, Diego; Calabria, Francesca; Monaco, Salvatore; Reindl, Markus; Ferrari, Sergio; Gajofatto, Alberto

Titolo:

NfL levels predominantly increase at disease onset in MOG-Abs-associated disorders

Anno:

2021

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

MULTIPLE SCLEROSIS AND RELATED DISORDERS

ISSN Rivista:

2211-0348

N° Volume:

50

Numero o Fascicolo:

102833

Intervallo pagine:

1-4

Parole chiave:

MOG; MOGAD; Myelitis; Neurofilament light chain levels; NfL; Optic neuritis

Breve descrizione dei contenuti:

The unpredictable course and uncertain impact of relapses make treatment strategies of anti-myelin oligodendrocyte glycoprotein antibodies associated disorders (MOGAD) challenging. We analysed neurofilament light chain levels (NfL) in onset and follow-up sera of 18 patients with MOGAD to clarify the timing of axonal damage. In comparison with disease onset values (median 8.9 pg/mL, range 1.8-97), NfL levels remained stable or decreased in most follow-up measurements (n=52, median 6.7 pg/mL, range 0.2-207), including those measured on relapses. The predominant axonal damage occurs during onset, which could be the main driving factor of final disability, with subsequent relevant clinical and therapeutic implications.

Pagina Web:

https://doi.org/10.1016/j.msard.2021.102833

Id prodotto:

119504

Handle IRIS:

11562/1037061

ultima modifica:

9 novembre 2022

Citazione bibliografica:

Mariotto, Sara; Gastaldi, Matteo; Grazian, Luisa; Mancinelli, Chiara; Capra, Ruggero; Marignier, Romaine; Alberti, Daniela; Zanzoni, Serena; Schanda, Kathrin; Franciotta, Diego; Calabria, Francesca; Monaco, Salvatore; Reindl, Markus; Ferrari, Sergio; Gajofatto, Alberto, NfL levels predominantly increase at disease onset in MOG-Abs-associated disorders «MULTIPLE SCLEROSIS AND RELATED DISORDERS» , vol. 50 , n. 102833 , 2021 , pp. 1-4

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