Publications

Authors:

Fasolo, Adriano; Galzignato, Alice; Pedrotti, Emilio; Chierego, Chiara; Cozzini, Tiziano; Bonacci, Erika; Marchini, Giorgio

Title:

Femtosecond laser-assisted implantation of corneal stroma lenticule for keratoconus

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

International Ophthalmology

ISSN of journal:

0165-5701

N° Volume:

41

Number or Folder:

5

Page numbers:

1949-1957

Keyword:

Additive keratoplasty; Corneal stroma lenticule implantation; Femtosecond laser; Intrastromal inlay; Keratoconus; Stromal keratophakia

Short description of contents:

PURPOSE: To review recent progress, challenges, and future perspectives of stromal keratophakia for the treatment of advanced keratoconus. METHODS: We systematically reviewed the literature in the PubMed database, last update June 30, 2020. No language restriction was applied. The authors checked the reference lists of the retrieved articles to identify any additional study of interest.RESULTS: Several techniques have been proposed for the treatment of keratoconus in order to avoid or delay keratoplasty. This was primarily due to the lack of accessibility to donor corneas in many countries. The ease and predictability of the more advanced femtosecond lasers used to correct ametropias by stromal lenticule extraction lead to hypothesize that generated refractive lenticules could be implanted into corneal stromal layers to restore volume and alter the refractive properties of the cornea in patients with corneal ectasias. At the same time, new techniques for preservation, customization, and cellular therapy of the corneal stromal have been developed, directing to the valorization of otherwise discarded byproducts such as donor corneas unsuitable for either lamellar of penetrating keratoplasty.CONCLUSIONS: Femtosecond laser-assisted stromal keratophakia could be a suitable therapeutic option for the treatment of corneal ectasias, especially in patients with advanced keratoconus, providing biomechanical support recovering the pachimetry to nearly normal value at the same time. The accuracy and predictability of the refractive outcome are yet a critical issue and the patient eligible for the procedure still has to be characterized.

Web page:

https://doi.org/10.1007/s10792-021-01739-8

Product ID:

119701

Handle IRIS:

11562/1037534

Last Modified:

November 15, 2022

Bibliographic citation:

Fasolo, Adriano; Galzignato, Alice; Pedrotti, Emilio; Chierego, Chiara; Cozzini, Tiziano; Bonacci, Erika; Marchini, Giorgio, Femtosecond laser-assisted implantation of corneal stroma lenticule for keratoconus «International Ophthalmology» , vol. 41 , n. 5 , 2021 , pp. 1949-1957

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