Publications

Authors:

Maniscalco, Giorgia Teresa; Zekeridou, Anastasia; Allegorico, Lia; Ranieri, Angelo; Napolitano, Massimo; Pezzella, Marianna; Gatta, Luigi Della; Manzo, Valentino; Ferrari, Sergio; Mariotto, Sara

Title:

GAD65 autoimmunity after treatment with nivolumab: a multifocal presentation

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

NEUROLOGICAL SCIENCES

ISSN of journal:

1590-1874

N° Volume:

42

Number or Folder:

10

Page numbers:

4289-4291

Keyword:

Ataxia; Checkpoint inhibitor; Encephalitis; Epilepsy; GAD65; Stiff person syndrome

Short description of contents:

Introduction: Neurological disorders are considered rare complications of immune-checkpoint inhibitor. Case description: We report a 63-year-old man with recurrence of melanoma who presented epilepsy, limbic encephalitis, cerebellar ataxia, and stiff person syndrome soon after treatment with nivolumab, an immune-checkpoint inhibitor. On autoimmune screening, serum and CSF GAD65 were detected. Significant response to steroids and intravenous immunoglobulins were observed, but cancer recurred after nivolumab discontinuation in parallel with epileptic seizure and worsening of cognitive impairment and the patient died. Discussion: This case expands the spectrum of GAD65-associated conditions induced by immune-checkpoint inhibitor and underlines treatment complexity when both neurological complications and tumour recurrence occur.

Web page:

https://doi.org/10.1007/s10072-021-05312-0

Product ID:

121041

Handle IRIS:

11562/1043337

Last Modified:

November 14, 2022

Bibliographic citation:

Maniscalco, Giorgia Teresa; Zekeridou, Anastasia; Allegorico, Lia; Ranieri, Angelo; Napolitano, Massimo; Pezzella, Marianna; Gatta, Luigi Della; Manzo, Valentino; Ferrari, Sergio; Mariotto, Sara, GAD65 autoimmunity after treatment with nivolumab: a multifocal presentation «NEUROLOGICAL SCIENCES» , vol. 42 , n. 10 , 2021 , pp. 4289-4291

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