Publications

Authors:

Gallucci, Maurizio; Mazzarolo, Anna Paola; Focella, Lucia; Berlin, Elisa; Fiore, Vittorio; Di Paola, Francesco; Bendini, Matteo; Zanusso, Gianluigi; Fenoglio, Chiara; Galimberti, Daniela; Bonanni, Laura

Title:

More atypical than atypical Alzheimer's disease phenotypes: a Treviso Dementia (TREDEM) registry case report

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

JOURNAL OF ALZHEIMER'S DISEASE REPORTS

ISSN of journal:

2542-4823

N° Volume:

5

Number or Folder:

1

Page numbers:

365-374

Keyword:

Alzheimer’s disease; PET scan; TREDEM; frontal variant; magnetic resonance; neurodegenerative diseases; posterior cortical atrophy

Short description of contents:

Background: A 57-year-old right-handed man was admitted to the Treviso Memory Clinic due to the presence of memory forgetfulness, repetition of the same questions, episodes of confusion, initial difficulties in performing complex tasks and easy distraction over the past two years, as well as recurrent and never-happened-before car accidents.Objective: We report a peculiar case of an early onset Alzheimer's disease (AD) with an unusual symptomatology, apparently not fitting in any of the categorized atypical forms of AD nor being representative of a typical amnestic AD.Methods: The patient underwent a neuropsychological, structural, and metabolic cerebral evaluation by MRI and F-18-FDG PET, together with the search for cerebral amyloid (amyloid PET), a genetic testing for dementia related genes and the dosage of CSF protein biomarkers of neurodegenerative conditions.Results: We observed a convergence of predominant frontal (dysexecutive, verbal disinhibition) and posterior (visuospatial) features of cognitive impairment. Structural MRI sequences showed subarachnoid spaces of the vault enlarged in the frontoparietal region with anterior and posterior cortical atrophy. The hippocampus appeared preserved. The 18F-FDG PET scans showed hypometabolism in the prefrontal, lateral temporal, posterior parietal, and occipital regions bilaterally. The F-18-Flutemetamol scan showed a diffused uptake of the amyloid tracer at the cerebral cortex. CSF biomarkers were compatible with Alzheimer's disease (AD).Conclusion: This case report presented with clinical phenotypic aspects atypical of AD, both frontal and posterior, never described as concomitant in the most accredited criteria for atypical AD, and appeared therefore more atypical than each of the atypical AD phenotypes already reported.

Web page:

https://doi.org/10.3233/adr-210009

Product ID:

121668

Handle IRIS:

11562/1045543

Last Modified:

November 15, 2022

Bibliographic citation:

Gallucci, Maurizio; Mazzarolo, Anna Paola; Focella, Lucia; Berlin, Elisa; Fiore, Vittorio; Di Paola, Francesco; Bendini, Matteo; Zanusso, Gianluigi; Fenoglio, Chiara; Galimberti, Daniela; Bonanni, Laura, More atypical than atypical Alzheimer's disease phenotypes: a Treviso Dementia (TREDEM) registry case report «JOURNAL OF ALZHEIMER'S DISEASE REPORTS» , vol. 5 , n. 1 , 2021 , pp. 365-374

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