Publications

Authors:

Porru, Stefano; Monaco, Maria Grazia Lourdes; Carta, Angela; Spiteri, Gianluca; Parpaiola, Marco; Battaggia, Andrea; Galligioni, Giulia; Ferrazzi, Beatrice; Lo Cascio, Giuliana; Gibellini, Davide; Peretti, Angelo; Brutti, Martina; Tardivo, Stefano; Ghirlanda, Giovanna; Verlato, Giuseppe; Gaino, Stefania; Peserico, Denise; Bassi, Antonella; Lippi, Giuseppe

Title:

SARS-CoV-2 infection in health workers: analysis from Verona SIEROEPID Study during the pre-vaccination era

Year:

2021

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH

ISSN of journal:

1660-4601

N° Volume:

18

Number or Folder:

6446

Page numbers:

1-11

Keyword:

SARS-CoV-2 infection; health workers; serosurvey

Short description of contents:

Background: To report the baseline phase of the SIEROEPID study on SARS-CoV-2 infection seroprevalence among health workers at the University Hospital of Verona, Italy, between spring and fall 2020; to compare performances of several laboratory tests for SARS-CoV-2 antibody detection. Methods: 5299 voluntary health workers were enrolled from 28 April 2020 to 28 July 2020 to assess immunological response to SARS-CoV-2 infection throughout IgM, IgG and IgA serum levels titration by four laboratory tests. Association of antibody titre with several demographic variables, swab tests and performance tests (sensitivity, specificity, and agreement) were statistically analyzed. Results: The overall seroprevalence was 6%, considering either IgG and IgM, and 4.8% considering IgG. Working in COVID-19 Units was not associated with a statistically significant increase in the number of infected workers. Cohen's kappa of agreement between MaglumiTM and VivaDiagTM was quite good when considering IgG only (Cohen's kappa = 78.1%, 95% CI 74.0-82.0%), but was lower considering IgM (Cohen's kappa = 13.3%, 95% CI 7.8-18.7%). Conclusion: The large sample size with high participation (84.7%), the biobank and the longitudinal design were significant achievements, offering a baseline dataset as the benchmark for risk assessment, health surveillance and management of SARS-CoV-2 infection for the hospital workforce, especially considering the ongoing vaccination campaign. Study results support the national regulator guidelines on using swabs for SARS-CoV-2 screening with health workers and using the serological tests to contribute to the epidemiological assessment of the spread of the virus.

Web page:

https://doi.org/10.3390/ijerph18126446

Product ID:

121733

Handle IRIS:

11562/1045712

Last Modified:

November 15, 2022

Bibliographic citation:

Porru, Stefano; Monaco, Maria Grazia Lourdes; Carta, Angela; Spiteri, Gianluca; Parpaiola, Marco; Battaggia, Andrea; Galligioni, Giulia; Ferrazzi, Beatrice; Lo Cascio, Giuliana; Gibellini, Davide; Peretti, Angelo; Brutti, Martina; Tardivo, Stefano; Ghirlanda, Giovanna; Verlato, Giuseppe; Gaino, Stefania; Peserico, Denise; Bassi, Antonella; Lippi, Giuseppe, SARS-CoV-2 infection in health workers: analysis from Verona SIEROEPID Study during the pre-vaccination era «INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH» , vol. 18 , n. 6446 , 2021 , pp. 1-11

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