Publications

Authors:

Salvalaggio, Alessandro; Coraci, Daniele; Obici, Laura; Cacciavillani, Mario; Luigetti, Marco; Mazzeo, Anna; Pastorelli, Francesca; Grandis, Marina; Cavallaro, Tiziana; Bisogni, Giulia; Lozza, Alessandro; Gemelli, Chiara; Gentile, Luca; Russo, Massimo; Ermani, Mario; Fabrizi, Gian Maria; Plasmati, Rosaria; De Napoli, Federica; Campagnolo, Marta; Castellani, Francesca; Salvi, Fabrizio; Fenu, Silvia; Devigili, Grazia; Pareyson, Davide; Gasparotti, Roberto; Rapezzi, Claudio; Martinoli, Carlo; Padua, Luca; Briani, Chiara

Title:

Progressive brachial plexus enlargement in hereditary transthyretin amyloidosis

Year:

2022

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Journal of Neurology

ISSN of journal:

0340-5354

N° Volume:

269

Number or Folder:

4

Page numbers:

1905-1912

Keyword:

Amyloidosis; Brachial plexus; Peripheral nerves; Transthyretin; Ultrasound

Short description of contents:

Axonal polyneuropathy is the main feature of hereditary transthyretin amyloidosis (ATTRv). Nerve morphological abnormalities have been reported, but longitudinal changes have never been assessed. We performed a prospective widespread nerve ultrasound evaluation and nerve cross-sectional area (CSA) was compared with baseline data in both ATTRv patients and pre-symptomatic carriers. Thirty-eight subjects were evaluated (mean follow-up 17.1 months), among them 21 had polyneuropathy while 17 were pre-symptomatic carriers. CSA significantly increased at brachial plexus in both groups (p = 0.008 and p = 0.012) pointing to progressive brachial plexus enlargement as a longitudinal biomarker of both disease progression and disease occurrence in pre-symptomatic carriers.

Web page:

https://doi.org/10.1007/s00415-021-10754-9

Product ID:

122115

Handle IRIS:

11562/1047521

Last Modified:

November 15, 2022

Bibliographic citation:

Salvalaggio, Alessandro; Coraci, Daniele; Obici, Laura; Cacciavillani, Mario; Luigetti, Marco; Mazzeo, Anna; Pastorelli, Francesca; Grandis, Marina; Cavallaro, Tiziana; Bisogni, Giulia; Lozza, Alessandro; Gemelli, Chiara; Gentile, Luca; Russo, Massimo; Ermani, Mario; Fabrizi, Gian Maria; Plasmati, Rosaria; De Napoli, Federica; Campagnolo, Marta; Castellani, Francesca; Salvi, Fabrizio; Fenu, Silvia; Devigili, Grazia; Pareyson, Davide; Gasparotti, Roberto; Rapezzi, Claudio; Martinoli, Carlo; Padua, Luca; Briani, Chiara, Progressive brachial plexus enlargement in hereditary transthyretin amyloidosis «Journal of Neurology» , vol. 269 , n. 4 , 2022 , pp. 1905-1912

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