Publications

Authors:

Dinoto, Alessandro; Mckeon, Andrew; Vattemi, Gaetano; Carta, Sara; Ferrari, Sergio; Mariotto, Sara

Title:

Neuronal intermediate filament paraneoplastic autoimmunity complicating avelumab therapy of Merkel cell carcinoma

Year:

2022

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

Journal of Neuroimmunology

ISSN of journal:

0165-5728

N° Volume:

368

Number or Folder:

577882

Page numbers:

1-3

Keyword:

Avelumab; Immune checkpoint inhibitors; Immune-related adverse events; Neuronal intermediate filament; Paraneoplastic neurological syndromes

Short description of contents:

A 67-years-old woman developed subacute oculomotor nerve palsy and cerebellar gait instability while receiving avelumab as immunotherapy for Merkel cell carcinoma. Brain MRI revealed oculomotor nerve T2/FLAIR hyperintensity and contrast enhancement, CSF cell number and protein concentration were slightly increased. Antibodies against intracellular and surface antigens were excluded through commercial assays, but home-made immunohistochemistry on rat brain sections showed a "neurofilament-like" pattern. Antibodies against neuronal intermediate filament (NIF-IgG) were thus tested and resulted positive in both serum and CSF, confirming the diagnosis of NIF-IgG autoimmunity. Avelumab was discontinued and treatment with steroids and intravenous immunoglobulins led to partial improvement.

Web page:

https://doi.org/10.1016/j.jneuroim.2022.577882

Product ID:

126872

Handle IRIS:

11562/1065104

Last Modified:

June 26, 2024

Bibliographic citation:

Dinoto, Alessandro; Mckeon, Andrew; Vattemi, Gaetano; Carta, Sara; Ferrari, Sergio; Mariotto, Sara, Neuronal intermediate filament paraneoplastic autoimmunity complicating avelumab therapy of Merkel cell carcinoma «Journal of Neuroimmunology» , vol. 368 , n. 577882 , 2022 , pp. 1-3

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo