Publications

Authors:

Rossi, Alice; Bragonzi, Alessandra; Medede, Melessike; De Fino, Ida; Lippi, Giuseppe; Prosdocimi, Marco; Tamanini, Anna; Cabrini, Giulio; Dechecchi, Maria Cristina

Title:

β-sitosterol ameliorates inflammation and Pseudomonas aeruginosa lung infection in a mouse model

Year:

2023

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Journal of Cystic Fibrosis

ISSN of journal:

1569-1993

N° Volume:

22

Number or Folder:

1

:

Elsevier

Page numbers:

156-160

Keyword:

β-sitosterol, inflammation, Pseudomonas aeruginosa, CYstic Fibrosis

Short description of contents:

We previously demonstrated that β-sitosterol (BSS) inhibits the expression of the chemokine IL-8 in CF bronchial epithelial cells exposed to P. aeruginosa. In the mouse model of lung chronic infection, herein shown, BSS significantly reduced leukocyte recruitment in the bronchoalveolar lavage fluid and decreased bacteria recovered in the airways. Treatment with BSS decreased the expression of key cytokines involved in immune response, mainly neutrophil chemotaxis, in the lung homogenate. This anti-inflammatory activity is accompanied by a beneficial protecting activity against infection and improvement of health status. Our data suggest that BSS has the potential to become a new drug to target the excessive neutrophil recruitment in lungs chronically infected by P. aeruginosa and encourage future investigations on mechanism of protection driven by BSS.

Web page:

https://linkinghub.elsevier.com/retrieve/pii/S1569199322006427

Product ID:

128417

Handle IRIS:

11562/1072735

Last Modified:

April 18, 2023

Bibliographic citation:

Rossi, Alice; Bragonzi, Alessandra; Medede, Melessike; De Fino, Ida; Lippi, Giuseppe; Prosdocimi, Marco; Tamanini, Anna; Cabrini, Giulio; Dechecchi, Maria Cristina, β-sitosterol ameliorates inflammation and Pseudomonas aeruginosa lung infection in a mouse model «Journal of Cystic Fibrosis» , vol. 22 , n. 1 , 2023 , pp. 156-160

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