Pubblicazioni

Autori:

Rossi, Alice; Bragonzi, Alessandra; Medede, Melessike; De Fino, Ida; Lippi, Giuseppe; Prosdocimi, Marco; Tamanini, Anna; Cabrini, Giulio; Dechecchi, Maria Cristina

Titolo:

β-sitosterol ameliorates inflammation and Pseudomonas aeruginosa lung infection in a mouse model

Anno:

2023

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Journal of Cystic Fibrosis

ISSN Rivista:

1569-1993

N° Volume:

22

Numero o Fascicolo:

1

Editore:

Elsevier

Intervallo pagine:

156-160

Parole chiave:

β-sitosterol, inflammation, Pseudomonas aeruginosa, CYstic Fibrosis

Breve descrizione dei contenuti:

We previously demonstrated that β-sitosterol (BSS) inhibits the expression of the chemokine IL-8 in CF bronchial epithelial cells exposed to P. aeruginosa. In the mouse model of lung chronic infection, herein shown, BSS significantly reduced leukocyte recruitment in the bronchoalveolar lavage fluid and decreased bacteria recovered in the airways. Treatment with BSS decreased the expression of key cytokines involved in immune response, mainly neutrophil chemotaxis, in the lung homogenate. This anti-inflammatory activity is accompanied by a beneficial protecting activity against infection and improvement of health status. Our data suggest that BSS has the potential to become a new drug to target the excessive neutrophil recruitment in lungs chronically infected by P. aeruginosa and encourage future investigations on mechanism of protection driven by BSS.

Pagina Web:

https://linkinghub.elsevier.com/retrieve/pii/S1569199322006427

Id prodotto:

128417

Handle IRIS:

11562/1072735

ultima modifica:

18 aprile 2023

Citazione bibliografica:

Rossi, Alice; Bragonzi, Alessandra; Medede, Melessike; De Fino, Ida; Lippi, Giuseppe; Prosdocimi, Marco; Tamanini, Anna; Cabrini, Giulio; Dechecchi, Maria Cristina, β-sitosterol ameliorates inflammation and Pseudomonas aeruginosa lung infection in a mouse model «Journal of Cystic Fibrosis» , vol. 22 , n. 1 , 2023 , pp. 156-160

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