Publications

Authors:

Pedrinolla, Anna; Cavedon, Valentina; Milanese, Chiara; Barbi, Chiara; Giuriato, Gaia; Laginestra, Fabio Giuseppe; Martignon, Camilla; Schena, Federico; Venturelli, Massimo

Title:

The role of muscle mass in vascular remodeling: insights from a single-leg amputee model

Year:

2023

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

European Journal of Applied Physiology

ISSN of journal:

1439-6319

N° Volume:

123

Number or Folder:

3

Page numbers:

523-531

Keyword:

vascular remodelling; arterial diameter,; muscle mass; amputee

Short description of contents:

Purpose: Both muscle mass and physical activity are independent mechanisms that play a role in vascular remodeling, however, the direct impact of muscle mass on the structure and function of the vessels is not clear. The aim of the study was to determine the impact of muscle mass alteration on lower limbs arterial diameter, blood flow, shear rate and arterial stiffness. Methods: Nine (33 ± 13 yrs) male individuals with a single-leg amputation were recruited. Vascular size (femoral artery diameter), hemodynamics (femoral artery blood flow and shear rate were measured at the level of the common femoral artery in both amputated (AL) and whole limbs (WL). Muscle mass of both limbs, including thigh for AL and thigh and leg for WL, was measured with a DXA system. Results: AL muscle mass was reduced compared to the WL (3.2 ± 1.2 kg vs. 9.4 ± 2.1 kg; p = 0.001). Diameter of the femoral artery was reduced in the AL (0.5 ± 0.1 cm) in comparison to the WL (0.9 ± 0.2 cm, p = 0.001). However, femoral artery blood flow normalized for the muscle mass (AL = 81.5 ± 78.7ml min-1 kg-1,WL = 32.4 ± 18.3; p = 0.11), and blood shear rate (AL = 709.9 ± 371.4 s-1, WL = 526,9 ± 295,6; p = 0.374) were non different between limbs. A correlation was found only between muscle mass and femoral artery diameter (p = 0.003, R = 0.6561). Conclusion: The results of this study revealed that the massive muscle mass reduction caused by a leg amputation, but independent from the level of physical activity, is coupled by a dramatic arterial diameter decrease. Interestingly, hemodynamics and arterial stiffness do not seem to be impacted by these structural changes.

Web page:

https://doi.org/10.1007/s00421-022-05076-1

Product ID:

130123

Handle IRIS:

11562/1078006

Last Modified:

March 28, 2023

Bibliographic citation:

Pedrinolla, Anna; Cavedon, Valentina; Milanese, Chiara; Barbi, Chiara; Giuriato, Gaia; Laginestra, Fabio Giuseppe; Martignon, Camilla; Schena, Federico; Venturelli, Massimo, The role of muscle mass in vascular remodeling: insights from a single-leg amputee model «European Journal of Applied Physiology» , vol. 123 , n. 3 , 2023 , pp. 523-531

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo