Publications

Authors:

Gecaite-Stonciene, Julija; Hughes, Brian M; Kazukauskiene, Nijole; Bunevicius, Adomas; Burkauskas, Julius; Neverauskas, Julius; Bellani, Marcella; Mickuviene, Narseta

Title:

Cortisol response to psychosocial stress, mental distress, fatigue and quality of life in coronary artery disease patients

Year:

2022

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

SCIENTIFIC REPORTS

ISSN of journal:

2045-2322

N° Volume:

12

Number or Folder:

19373

Page numbers:

1-12

Keyword:

Hydrocortisone; Quality of Life; Cross-Sectional Studies; Anxiety; Stress, Psychological; Depression; Coronary Artery Disease; Acute Coronary Syndrome

Short description of contents:

We aimed to explore the relationship between cortisol response to psychosocial stress, mental distress, fatigue and health related quality of life (HRQoL) in individuals with coronary artery disease (CAD) after recent acute coronary syndrome (ACS). A cross-sectional study initially included 113 subjects (88% men, 53 ± 7 years) 1-3 weeks after ACS. Cortisol response was assessed by measuring salivary cortisol during Trier Social Stress Test. Mental distress was measured with Hospital Anxiety and Depression Scale, State-Trait Anxiety Inventory, and Type D Scale-14. Fatigue symptoms were evaluated using Multidimensional Fatigue Inventory 20-items, while HRQoL was assessed with 36-Item Short Form Medical Outcome Questionnaire. After conducting multivariable linear regression analyses, diminished cortisol response sampled after Public speech (T3-T1, + 15 min) was significantly associated with higher anxiety symptoms (β = -0.224; p = 0.035), while diminished cortisol response sampled after preparation time (T2-T1, + 10 min) was significantly linked with the presence of Type D personality (β = -0.290; p = 0.006; β = -0.282; p = 0.008 respectively), even after controlling for confounders (i.e., sex, age, education, New York Heart Association functional class, beta-blockers and baseline levels of cortisol measures). We found that mental distress, but not fatigue and HRQoL, was linked with blunted cortisol response during anticipation time of psychosocial stress, independently of potential covariates.

Web page:

https://doi.org/10.1038/s41598-022-23712-w

Product ID:

130484

Handle IRIS:

11562/1078917

Last Modified:

February 23, 2023

Bibliographic citation:

Gecaite-Stonciene, Julija; Hughes, Brian M; Kazukauskiene, Nijole; Bunevicius, Adomas; Burkauskas, Julius; Neverauskas, Julius; Bellani, Marcella; Mickuviene, Narseta, Cortisol response to psychosocial stress, mental distress, fatigue and quality of life in coronary artery disease patients «SCIENTIFIC REPORTS» , vol. 12 , n. 19373 , 2022 , pp. 1-12

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