Pubblicazioni

Autori:

Zovetti, Niccolò; Rossetti, Maria Gloria; Perlini, Cinzia; Brambilla, Paolo; Bellani, Marcella

Titolo:

Brain ageing and neurodegeneration in bipolar disorder

Anno:

2023

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Journal of Affective Disorders

ISSN Rivista:

0165-0327

N° Volume:

323

Intervallo pagine:

171-175

Parole chiave:

Brain ageing; Degeneration; Neuroimaging

Breve descrizione dei contenuti:

Background: Bipolar disorder (BD) is a psychiatric condition characterized by alternating episodes of mania and depression frequently associated with cognitive impairments. BD is associated with brain alterations in fronto-temporal and limbic networks. Recent conceptualizations view BD as a neurodegenerative disorder characterized by progressive deterioration of grey and white matter (GM, WM) volumes and accelerated brain ageing. Therefore, we conducted a review gathering neuroimaging evidence about neurodegenerative processes in BD. Methods: A literature search was conducted on the PubMed, Scopus and Web of Science databases in September 2021. After title and abstract screening of the retrieved records, 19 studies meeting our inclusion criteria were included in the review. Results: Our review suggests the presence of a progressive reduction of GM volumes at the whole-brain level and in the amygdala, prefrontal regions and the anterior cingulate cortex. Conversely, WM lesions and alterations seem to emerge only in the early phases of the condition masking the effects of normal ageing. Lastly, machine learning models indicate that the gap between predicted and chronological brain age differs considerably between healthy controls and BD patients, as the latter are characterized by greater gaps. Limitations: The included studies have cross-sectional study design, small sample sizes and heterogeneous methodology, and lack of control for pharmacological treatment. Conclusions: BD seems to be associated with generalized age-related structural GM volumes reduction and functional brain alterations thus suggesting the presence of neurodegenerative processes. Future systematic reviews and meta-analyses should be conducted to quantify the magnitude of brain ageing-related effects in BD.

Pagina Web:

https://doi.org/10.1016/j.jad.2022.11.066

Id prodotto:

130291

Handle IRIS:

11562/1079612

ultima modifica:

23 febbraio 2023

Citazione bibliografica:

Zovetti, Niccolò; Rossetti, Maria Gloria; Perlini, Cinzia; Brambilla, Paolo; Bellani, Marcella, Brain ageing and neurodegeneration in bipolar disorder «Journal of Affective Disorders» , vol. 323 , 2023 , pp. 171-175

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