Publications

Authors:

Velasco, R.; Argyriou, A. A.; Marco, C.; Mariotto, S.; Stradella, A.; Hernández, J.; Pernas, S.; Ferrari, S.; Bruna , J.

Title:

Serum neurofilament levels correlate with electrodiagnostic evidence of axonal loss in paclitaxel-induced peripheral neurotoxicity

Year:

2023

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Journal of Neurology

ISSN of journal:

0340-5354

N° Volume:

270

Number or Folder:

1

Page numbers:

531-537

Keyword:

Chemotherapy-induced peripheral neuropathy; Nerve conduction studies; Neurofilament light chain; Neurotoxicity; Paclitaxel

Short description of contents:

Introduction: Paclitaxel-induced peripheral neurotoxicity (PIPN) typically manifests as a predominantly sensory axonopathy. Nerve conduction studies (NCS) represent the gold standard method to quantify axonal impairment in PIPN. Serum neurofilament light chain (sNfL) levels are emerging biomarkers for quantifying axonal damage in peripheral neuropathies. To date, the association between NCS abnormalities and sNfL levels during paclitaxel-based chemotherapy has not been specifically addressed. Methods: We prospectively conducted longitudinal measurement of sNfL levels in 27 chemotherapy-naïve breast cancer patients and correlated conventional NCS recordings with sNfL in 22 of them, before (T0) and after (T1) 12 cycles of weekly paclitaxel-based therapy. Results: PIPN was diagnosed in 24/27 patients (88%) after completion of the 12-week paclitaxel-based chemotherapy regimen. Serum NfL levels (pg/mL) were significantly higher at T1 compared to T0 (T0: 18.50 ± 12.88 vs T1: 255.80 ± 194.16; p < 0.001). The increase of sNfL levels at T1 significantly correlated with the decrease or abolishment of amplitudes recorded from the sural nerve (r = 0.620; p = 0.0035), sensory radial (r = 0.613; p = 0.005), sensory ulnar (r = 0.630; p = 0.005), and peroneal motor (r = 0.568; p = 0.024) nerves. Conclusion: sNfL levels proportionally increase during chemotherapy administration and significantly correlate with NCS axonal abnormalities in patients with PIPN. A multimodal testing approach employing both sNfL and NCS might improve the PIPN diagnostic accuracy.

Web page:

https://doi.org/10.1007/s00415-022-11377-4

Product ID:

130757

Handle IRIS:

11562/1080543

Last Modified:

February 23, 2023

Bibliographic citation:

Velasco, R.; Argyriou, A. A.; Marco, C.; Mariotto, S.; Stradella, A.; Hernández, J.; Pernas, S.; Ferrari, S.; Bruna , J., Serum neurofilament levels correlate with electrodiagnostic evidence of axonal loss in paclitaxel-induced peripheral neurotoxicity «Journal of Neurology» , vol. 270 , n. 1 , 2023 , pp. 531-537

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