Publications

Authors:

Ostuzzi, Giovanni; Tedeschi, Federico; Bertolini, Federico; Cotugno, Carlo; Aguglia, Andrea; Bartoli, Francesco; Carrà, Giuseppe; D'Agostino, Armando; Martinotti, Giovanni; Barbui, Corrado; Gastaldon, Chiara; Papola, Davide

Title:

Clinical trajectories of individuals with severe mental illness continuing and discontinuing long-acting antipsychotics: a one-year mirror-image analysis from the STAR Network Depot study

Year:

2023

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

SCHIZOPHRENIA

ISSN of journal:

2754-6993

N° Volume:

9

Number or Folder:

23

Page numbers:

1-8

Keyword:

psychosis; schizophrenia; long-acting antipsychotics; clinical outcome

Short description of contents:

Evidence on long-acting antipsychotics (LAIs) in unselected populations with severe mental illness is scant. In this mirror-image study, we compared multiple clinical outcomes 1 year before and after a first LAI prescription in adults with severe mental illness, describing clinical trajectories of LAI continuers and discontinuers. We compared LAI continuers and discontinuers through Mann-Whitney U test, Kaplan-Meier survival curves, regression for interval-censored data, and a maximum-likelihood mixed-model with individual random-effect and time as predictor. Of the 261 participants analyzed, 71.3% had schizophrenia-spectrum disorders, and 29.5% discontinued the LAI before 1 year. At baseline, LAI discontinuers had a shorter illness duration, lower attitude and adherence scores. The mirror-image analysis showed reduced hospital admissions only for LAI continuers. Over time, continuers spent less days hospitalized, but had more adverse events and more antipsychotics prescribed, with higher overall doses. In conclusion, this study shows that LAIs might be beneficial in unselected patient populations, provided that adherence is maintained. LAI continuers spent less time hospitalized, but received more antipsychotics and suffered from more cumulative adverse events over time. Therefore, the choice of initiating and maintaining a LAI should be carefully weighed on a case-by-case basis.

Web page:

https://doi.org/10.1038/s41537-023-00342-3

Product ID:

133381

Handle IRIS:

11562/1092307

Last Modified:

April 22, 2023

Bibliographic citation:

Ostuzzi, Giovanni; Tedeschi, Federico; Bertolini, Federico; Cotugno, Carlo; Aguglia, Andrea; Bartoli, Francesco; Carrà, Giuseppe; D'Agostino, Armando; Martinotti, Giovanni; Barbui, Corrado; Gastaldon, Chiara; Papola, Davide, Clinical trajectories of individuals with severe mental illness continuing and discontinuing long-acting antipsychotics: a one-year mirror-image analysis from the STAR Network Depot study «SCHIZOPHRENIA» , vol. 9 , n. 23 , 2023 , pp. 1-8

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo