Publications

Authors:

Pedrinolla, Anna; Berg, Ole Kristian; Tøien, Tiril; Wang, Eivind

Title:

Aging increases metabolic capacity and reduces work efficiency during handgrip exercise in males

Year:

2023

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

JOURNAL OF APPLIED PHYSIOLOGY

ISSN of journal:

8750-7587

N° Volume:

134

Number or Folder:

5

:

American Physiological Society:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7180, EMAIL: subscrip@the-aps.org, INTERNET: http://www.the-aps.org, Fax: (301)571-8313

Page numbers:

1154-1164

Keyword:

V̇O2peak; forearm; muscle diffusion; vascular conductance; vascular function

Short description of contents:

Maximal oxygen uptake and exercise performance typically decline with age. However, there are indications of preserved vascular function and blood flow regulation during arm exercise. Yet, it is unknown if this potential physiological preservation with age is mirrored in peripheral metabolic capacity and V̇O2/watt ratio. Thus, to investigate the effects of aging in the arms, we measured metabolic and vascular responses to 6-minute bouts of dynamic handgrip exercise at 40% and 80% of maximal work rate (WRmax) in eleven young (26±2yr) and twelve old (80±6yr) males, applying Doppler-ultrasound combined with blood samples from a deep forearm vein. At baseline, old had a larger arterial diameter compared to young (p<0.001). During exercise, the two groups reached the same WRmax. V̇O2, blood flow, and oxygen supply were higher (40%WRmax; 80%WRmax, all p<0.01), and arterio-venous oxygen-difference lower (80%WRmax, p<0.02), in old compared to young. Old also had a higher oxygen-excess at 80%WRmax (p<0.01) than young, while no difference in muscle diffusion or oxygen-extraction was detected. Only young exhibited an increase in intensity-induced arterial dilation (p<0.05), and they had a lower mean arterial pressure than old at 80%WRmax (p<0.001). V̇O2/watt (40%WRmax; 80%WRmax) was reduced in old compared to young (both p<0.05). In conclusion, in old and young males with a similar handgrip WRmax, old had a higher V̇O2 during 80%WRmax intensity, achieved by an increased blood flow. This may be a result of the available cardiac output reserve, compensating for reduced work efficiency and attenuated vascular response observed in old.

Note:

A. Pedrinolla and O. K. Berg contributed equally to this work.

Web page:

https://doi.org/10.1152/japplphysiol.00411.2022

Product ID:

133380

Handle IRIS:

11562/1092308

Last Modified:

June 9, 2023

Bibliographic citation:

Pedrinolla, Anna; Berg, Ole Kristian; Tøien, Tiril; Wang, Eivind, Aging increases metabolic capacity and reduces work efficiency during handgrip exercise in males «JOURNAL OF APPLIED PHYSIOLOGY» , vol. 134 , n. 5 , 2023 , pp. 1154-1164

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