Publications

Authors:

Carta, Sara; Dinoto, Alessandro; Capobianco, Marco; Valentino, Paola; Montarolo, Francesca; Sala, Arianna; Reindl, Markus; Lo Re, Marianna; Chiodega, Vanessa; Branger, Pierre; Audoin, Bertrand; Aboab, Jennifer; Papeix, Caroline; Collongues, Nicolas; Kerschen, Philippe; Zephir, Helene; Créange, Alain; Bourre, Bertrand; Schanda, Kathrin; Flanagan, Eoin P; Redenbaugh, Vyanka; Villacieros-Álvarez, Javier; Arrambide, Georgina; Cobo-Calvo, Alvaro; Ferrari, Sergio; Marignier, Romain; Mariotto, Sara

Title:

Serum Biomarker Profiles Discriminate AQP4 Seropositive and Double Seronegative Neuromyelitis Optica Spectrum Disorder

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

NEUROLOGY® NEUROIMMUNOLOGY & NEUROINFLAMMATION

ISSN of journal:

2332-7812

N° Volume:

11

Number or Folder:

1

Page numbers:

1-10

Keyword:

n/a

Short description of contents:

Background and objectives: Glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) serum levels are useful to define disease activity in different neurologic conditions. These biomarkers are increased in patients with aquaporin-4 antibody-positive NMOSD (AQP4+NMOSD) during clinical attacks suggesting a concomitant axonal and glial damage. However, there are contradictory results in double seronegative NMOSD (DS-NMOSD). The aim of this study was to characterize the neuronal, axonal, and glial damage of DS-NMOSD in comparison with AQP4+NMOSD. Methods: Patients with DS-NMOSD (i.e., for AQP4 and myelin oligodendrocyte glycoprotein antibodies-MOG-Abs) and age-matched AQP4+NMOSD diagnosed according to the latest diagnostic criteria and with available serum samples obtained within 3 months from onset/relapse were retrospectively enrolled from 14 international centers. Clinical and radiologic data were collected. Serum NfL, GFAP, tau, and UCH-L1 levels were determined using an ultrasensitive paramagnetic bead-based ELISA (SIMOA). Statistical analysis was performed using nonparametric tests and receiver-operating characteristic (ROC) curve analysis. Results: We included 25 patients with AQP4+NMOSD and 26 with DS-NMOSD. The median age at disease onset (p = 0.611) and female sex predominance (p = 0.072) were similar in the 2 groups. The most common syndromes at sampling in both AQP4+NMOSD and DS-NMOSD were myelitis (56% vs 38.5%) and optic neuritis (34.6% vs 32%), with no statistical differences (p = 0.716). Median EDSS at sampling was 3.2 (interquartile range [IQR] 2-7.7) in the AQP4+NMOSD group and 4 (IQR [3-6]) in the DS-NMOSD group (p = 0.974). Serum GFAP, tau, and UCH-L1 levels were higher in patients with AQP4+NMOSD compared with those with DS-NMOSD (median 308.3 vs 103.4 pg/mL p = 0.001; median 1.2 vs 0.5 pg/mL, p = 0.001; and median 61.4 vs 35 pg/mL, p = 0.006, respectively). The ROC curve analysis showed that GFAP, tau, and UCH-L1, but not NfL, values were able to discriminate between AQP4+ and DS-NMOSD (area under the curve (AUC) tau: 0.782, p = 0.001, AUC GFAP: 0.762, p = 0.001, AUC UCH-L1: 0.723, p = 0.006). NfL levels were associated with EDSS at nadir only in patients with AQP4+NMOSD. Discussion: Serum GFAP, tau, and UCH-L1 levels discriminate between AQP4+NMOSD and DS-NMOSD. The different biomarker profile of AQP4+NMOSD vs DS-NMOSD suggests heterogeneity of diseases within the latter category and provides useful data to improve our understanding of this disease.

Web page:

https://www.neurology.org/doi/pdf/10.1212/NXI.0000000000200188

Product ID:

136816

Handle IRIS:

11562/1116250

Last Modified:

September 26, 2024

Bibliographic citation:

Carta, Sara; Dinoto, Alessandro; Capobianco, Marco; Valentino, Paola; Montarolo, Francesca; Sala, Arianna; Reindl, Markus; Lo Re, Marianna; Chiodega, Vanessa; Branger, Pierre; Audoin, Bertrand; Aboab, Jennifer; Papeix, Caroline; Collongues, Nicolas; Kerschen, Philippe; Zephir, Helene; Créange, Alain; Bourre, Bertrand; Schanda, Kathrin; Flanagan, Eoin P; Redenbaugh, Vyanka; Villacieros-Álvarez, Javier; Arrambide, Georgina; Cobo-Calvo, Alvaro; Ferrari, Sergio; Marignier, Romain; Mariotto, Sara, Serum Biomarker Profiles Discriminate AQP4 Seropositive and Double Seronegative Neuromyelitis Optica Spectrum Disorder «NEUROLOGY® NEUROIMMUNOLOGY & NEUROINFLAMMATION» , vol. 11 , n. 1 , 2024 , pp. 1-10

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