Publications

Authors:

Zamboni, Lorenzo; Portoghese, Igor; Casari, Rebecca; Fusina, Francesca; Santin, Laura; Lecca, Luigi Isaia; Campagnari, Simone; Carli, Silvia; Zandonai, Thomas; Lugoboni, Fabio

Title:

High-dose benzodiazepine use and QTc interval prolongation, a latent class analysis study

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

SCIENTIFIC REPORTS

ISSN of journal:

2045-2322

N° Volume:

14

Number or Folder:

1

Page numbers:

1-10

Keyword:

Cardiology; Medical research; Psychology

Short description of contents:

Benzodiazepine (BDZ) addiction is a widespread and multifaceted phenomenon. For many patients, especially females, the concomitant use of other drugs also increases their risk of QTc prolongation, possibly leading to complications such as seizures and even sudden death. However, the relationship between BDZ use and QTc prolongation is currently unclear. The present study aims to examine patterns of polysubstance use among a sample of Italian adults with BDZ dependence in relation with their QTc prolongation risk. We used Latent Class Analysis (LCA) on data collected from 251 inpatients of the Addiction Medicine Unit in Verona to group patients into three classes according to their substance use and their QTc prolongation risk. Results showed no significant relationship between QTc prolongation and BDZ use in any of the classes considered. We conclude that BDZs, even if used long-term and at high dosages, can be considered safe in terms of cardiovascular complications for patients.

Web page:

https://doi.org/10.1038/s41598-023-50489-3

Product ID:

136985

Handle IRIS:

11562/1116780

Last Modified:

May 26, 2024

Bibliographic citation:

Zamboni, Lorenzo; Portoghese, Igor; Casari, Rebecca; Fusina, Francesca; Santin, Laura; Lecca, Luigi Isaia; Campagnari, Simone; Carli, Silvia; Zandonai, Thomas; Lugoboni, Fabio, High-dose benzodiazepine use and QTc interval prolongation, a latent class analysis study «SCIENTIFIC REPORTS» , vol. 14 , n. 1 , 2024 , pp. 1-10

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