Pubblicazioni

Autori:

Bianchi, Alessia; Matranga, Domenica; Patti, Francesco; Maniscalco, Laura; Pilotto, Silvy; Di Filippo, Massimiliano; Zaffaroni, Mauro; Annovazzi, Pietro; Bertolotto, Antonio; Gasperini, Claudio; Quartuccio, Esmeralda; Centonze, Diego; Fantozzi, Roberta; Gajofatto, Alberto; Gobbin, Francesca; Landi, Doriana; Granella, Franco; Buccafusca, Maria; Marfia, Girolama Alessandra; Chisari, Clara; Naldi, Paola; Bergamaschi, Roberto; Greco, Giacomo; Zarbo, Ignazio Roberto; Rizzo, Vincenzo; Ulivelli, Monica; Bezzini, Daiana; Florio, Lucia; Turazzini, Michelangelo; Di Gregorio, Maria; Pugliatti, Maura; Salemi, Giuseppe; Ragonese, Paolo

Titolo:

The role of ethnicity and native-country income in multiple sclerosis: the Italian multicentre study (MS-MigIT)

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Journal of Neurology

ISSN Rivista:

0340-5354

N° Volume:

271

Numero o Fascicolo:

5

Intervallo pagine:

2182-2194

Parole chiave:

Case–control study; Ethnic group; Geographical factors; Income; Migration; Multiple sclerosis

Breve descrizione dei contenuti:

Objective: Multiple sclerosis (MS) is a complex disorder in which environmental and genetic factors interact modifying disease risk and course. This multicentre, case-control study involving 18 Italian MS Centres investigated MS course by ethnicity and native-country economic status in foreign-born patients living in Italy. Methods: We identified 457 MS patients who migrated to Italy and 893 age- and sex-matched native-born Italian patients. In our population, 1225 (93.2%) subjects were White Europeans and White Northern Americans (WENA) and 89 (6.8%) patients were from other ethnical groups (OEG); 1109 (82.1%) patients were born in a high-income (HI) Country and 241 (17.9%) in a low-middle-income (LMI) Country. Medical records and patients interviews were used to collect demographic and disease data. Results: We included 1350 individuals (973 women and 377 men); mean (SD) age was 45.0 (11.7) years. At onset, 25.45% OEG patients vs 12.47% WENA (p = 0.039) had > 3 STIR spine lesions. At recruitment, the same group featured mean (SD) EDSS score of 2.85 (2.23) vs 2.64 (2.28) (p = 0.044) reached in 8.9 (9.0) vs 12.0 (9.0) years (p = 0.018) and underwent 1.10 (4.44) vs. 0.99 (0.40) annual MRI examinations (p = 0.035). At disease onset, patients from LMI countries had higher EDSS score than HI patients (2.40 (1.43) vs 1.99 (1.17); p = 0.032). Discussion: Our results suggested that both ethnicity and socio-economic status of native country shape MS presentation and course and should be considered for an appropriate management of patients. To the best of our knowledge, this is the first study reporting on the impact of ethnicity in MS at an individual level and beyond an ecological population-perspective.

Pagina Web:

https://doi.org/10.1007/s00415-024-12214-6

Id prodotto:

137828

Handle IRIS:

11562/1119487

ultima modifica:

26 giugno 2024

Citazione bibliografica:

Bianchi, Alessia; Matranga, Domenica; Patti, Francesco; Maniscalco, Laura; Pilotto, Silvy; Di Filippo, Massimiliano; Zaffaroni, Mauro; Annovazzi, Pietro; Bertolotto, Antonio; Gasperini, Claudio; Quartuccio, Esmeralda; Centonze, Diego; Fantozzi, Roberta; Gajofatto, Alberto; Gobbin, Francesca; Landi, Doriana; Granella, Franco; Buccafusca, Maria; Marfia, Girolama Alessandra; Chisari, Clara; Naldi, Paola; Bergamaschi, Roberto; Greco, Giacomo; Zarbo, Ignazio Roberto; Rizzo, Vincenzo; Ulivelli, Monica; Bezzini, Daiana; Florio, Lucia; Turazzini, Michelangelo; Di Gregorio, Maria; Pugliatti, Maura; Salemi, Giuseppe; Ragonese, Paolo, The role of ethnicity and native-country income in multiple sclerosis: the Italian multicentre study (MS-MigIT) «Journal of Neurology» , vol. 271 , n. 5 , 2024 , pp. 2182-2194

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