Publications

Authors:

Giuriato, Gaia; Romanelli, Maria Grazia; Bartolini, Desirée; Vernillo, Gianluca; Pedrinolla, Anna; Moro, Tatiana; Franchi, Martino; Locatelli, Elena; Andani, Mehran Emadi; Laginestra, Fabio Giuseppe; Barbi, Chiara; Aloisi, Gloria Fiorini; Cavedon, Valentia; Milanese, Chiara; Orlandi, Elisa; De Simone, Tonia; Fochi, Stefania; Patuzzo, Cristina; Malerba, Giovanni; Fabene, Paolo; Donadelli, Massimo; Stabile, Anna Maria; Pistilli, Alessandra; Rende, Mario; Galli, Francesco; Schena, Federico; Venturelli, Massimo

Title:

Sex differences in neuromuscular and biological determinants of isometric maximal force

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

ACTA PHYSIOLOGICA (PRINT)

ISSN of journal:

1748-1708

N° Volume:

240

Number or Folder:

4

:

Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: journals.cs@blacksci.co.uk, INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205

Page numbers:

1-21

Keyword:

gut microbiota; miRNA; muscle force; muscle proteins; neuromuscular determinants; sex differences

Short description of contents:

Aim: Force expression is characterized by an interplay of biological and molecular determinants that are expected to differentiate males and females in terms of maximal performance. These include muscle characteristics (muscle size, fiber type, contractility), neuromuscular regulation (central and peripheral factors of force expression), and individual genetic factors (miRNAs and gene/protein expression). This research aims to comprehensively assess these physiological variables and their role as determinants of maximal force difference between sexes. Methods: Experimental evaluations include neuromuscular components of isometric contraction, intrinsic muscle characteristics (proteins and fiber type), and some biomarkers associated with muscle function (circulating miRNAs and gut microbiome) in 12 young and healthy males and 12 females. Results: Male strength superiority appears to stem primarily from muscle size while muscle fiber-type distribution plays a crucial role in contractile properties. Moderate-to-strong pooled correlations between these muscle parameters were established with specific circulating miRNAs, as well as muscle and plasma proteins. Conclusion: Muscle size is crucial in explaining the differences in maximal voluntary isometric force generation between males and females with similar fiber type distribution. Potential physiological mechanisms are seen from associations between maximal force, skeletal muscle contractile properties, and biological markers.

Web page:

https://doi.org/10.1111/apha.14118

Product ID:

138031

Handle IRIS:

11562/1120155

Last Modified:

April 26, 2024

Bibliographic citation:

Giuriato, Gaia; Romanelli, Maria Grazia; Bartolini, Desirée; Vernillo, Gianluca; Pedrinolla, Anna; Moro, Tatiana; Franchi, Martino; Locatelli, Elena; Andani, Mehran Emadi; Laginestra, Fabio Giuseppe; Barbi, Chiara; Aloisi, Gloria Fiorini; Cavedon, Valentia; Milanese, Chiara; Orlandi, Elisa; De Simone, Tonia; Fochi, Stefania; Patuzzo, Cristina; Malerba, Giovanni; Fabene, Paolo; Donadelli, Massimo; Stabile, Anna Maria; Pistilli, Alessandra; Rende, Mario; Galli, Francesco; Schena, Federico; Venturelli, Massimo, Sex differences in neuromuscular and biological determinants of isometric maximal force «ACTA PHYSIOLOGICA (PRINT)» , vol. 240 , n. 4 , 2024 , pp. 1-21

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