Publications

Authors:

Girelli, Francesca; Rossetti, Maria Gloria; Perlini, Cinzia; Bellani, Marcella

Title:

Neural correlates of cognitive behavioral therapy-based interventions for bipolar disorder: A scoping review

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Journal of Psychiatric Research

ISSN of journal:

0022-3956

N° Volume:

172

Page numbers:

351-359

Keyword:

Bipolar disorder; Cognitive behavioral therapy; MRI; Mindfulness; Neuroimaging; Psychotherapy

Short description of contents:

Cognitive Behavioral Therapy (CBT) is among the gold-standard psychotherapeutic interventions for the treatment of psychiatric disorders, including bipolar disorder (BD). While the clinical response of CBT in patients with BD has been widely investigated, its neural correlates remain poorly explored. Therefore, this scoping review aimed to discuss neuroimaging studies on CBT-based interventions in bipolar populations. Particular attention has been paid to similarities and differences between studies to inform future research. The literature search was conducted on PubMed, PsycINFO, and Web of Science databases in June 2023, identifying 307 de-duplicated records. Six studies fulfilled the inclusion criteria and were reviewed. All of them analyzed functional brain activity data. Four studies showed that the clinical response to CBT was associated with changes in the functional activity and/or connectivity of prefrontal and posterior cingulate cortices, temporal parietal junction, amygdala, precuneus, and insula. In two additional studies, a peculiar pattern of baseline activations in the prefrontal cortex, hippocampus, amygdala, and insula predicted post-treatment improvements in depressive symptoms, emotion dysregulation, and psychosocial functioning, although CBT-specific effects were not shown. These results suggest, at the very preliminary level, the potential of CBT-based interventions in modulating neural activity and connectivity of patients with BD, especially in regions ascribed to emotional processing. Nonetheless, the discrepancies between studies concerning aims, design, sample characteristics, and CBT and fMRI protocols do not allow conclusions to be drawn. Further research using multimodal imaging techniques, better-characterized BD samples, and standardized CBT-based interventions is needed.

Web page:

https://doi.org/10.1016/j.jpsychires.2024.02.054

Product ID:

138314

Handle IRIS:

11562/1121226

Last Modified:

May 29, 2024

Bibliographic citation:

Girelli, Francesca; Rossetti, Maria Gloria; Perlini, Cinzia; Bellani, Marcella, Neural correlates of cognitive behavioral therapy-based interventions for bipolar disorder: A scoping review «Journal of Psychiatric Research» , vol. 172 , 2024 , pp. 351-359

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